dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, someone check my working
#dosing-titration 2024-01-05
Friday20 messages4 participantstimes are UTC
Highlights from this day
- lot_number_lou — appetite returning at the end of the week is extremely common and is not the dose failing 17:39
- lot_number_lou — you do not have to escalate at all. that is a real option that gets forgotten 17:42
- HPLC_Hank — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 17:45
- vial_ledger — does a missed week reset anything or do you just carry on 18:12
- vial_ledger — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, still working it out 18:40
update question: did anyone who held for 16 months regret it
📉2
appetite returning at the end of the week is extremely common and is not the dose failing
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mln of 1
🔥1
you do not have to escalate at all. that is a real option that gets forgotten
🤝14👍2
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
🤝8👍8🧊10
not advice
does a missed week reset anything or do you just carry on
🧪11🧊3✅11
too early imo
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
go slower
is there any actual reason to escalate every 4 weeks other than the trial did it
i went from 12 to 2 and honestly could not tell the difference in appetite
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
with a roughly seven day half-life you are near steady state after about five weeks at a dose
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, still working it out
🎉15🤝1✅15
how do you tell a plateau from just being at your set point
[edited]if it "stopped working after four days" that is almost never pharmacokinetics
📉9🧊6
i escalate on symptoms. if the current dose is still doing something i stay on it