dropped the GLP-1 and stayed on this alone for 16 months, appetite held but weight barely moved, anyway
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#cagrilintide 2026-06-11
Thursday24 messages6 participantstimes are UTC
Highlights from this day
- rotate_the_site — dropped the GLP-1 and stayed on this alone for 16 months, appetite held but weight barely moved, anyway 17:17
- a1c_lag — its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake 17:34
- rotate_the_site — two VendorInvestigate results on the same MKM lot came back 96.8 and 99, closer than i expected 18:50
- baseline_drift — for the archive added it to an existing semaglutide dose rather than starting both, which made attribution possible, take that with a pinch of salt 19:37
- rotate_the_site — dosing them on different days made no difference i could detect monotherapy did work for me, just slower and smaller than i expected 19:53
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
[edited]❤️10👍7😂1
whats the recon people use, 10 in 0.5ml
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
combination for me
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
anyone holding at 10 for a while before stepping
did the combination change your GI compared to the GLP-1 alone
is the weekly schedule the same here
back after 19 months, is monotherapy still a minority thing here
slower than the others
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
coming back to this the fullness thing is the part people describe differently, food stops being interesting rather than repellent
held mine a while
two VendorInvestigate results on the same MKM lot came back 96.8 and 99, closer than i expected
Digest for the week of 2026-03-16 has been published.
monotherapy was underwhelming for me and i say that as someone who wanted it to work
i was sceptical about monotherapy and after 12 months im still sceptical, just less so
for the archive added it to an existing semaglutide dose rather than starting both, which made attribution possible, take that with a pinch of salt
chromatogram-overlay.png
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30 in 2ml gives 5mg/ml which is what i use, purely because the units come out round
two VendorInvestigate results on the same GL Biochem lot came back 99.2 and 99, closer than i expected
dosing them on different days made no difference i could detect
monotherapy did work for me, just slower and smaller than i expected
lot-log.csv
416 rows · not retained in the public archive
the nausea felt different rather than less, more fullness and less of the queasy wave
REDEFINE is the trial
monotherapy here
for the archive is the combination just the two dosed together or a single formulation