amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
#cagrilintide 2026-06-09
Tuesday21 messages4 participantstimes are UTC
Highlights from this day
- nate_nights — amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist 23:08
- chlorhex — stopped for 11 months and the fullness went within a fortnight of the last dose 23:30
- lot_number_lou — slightly off topic but dropped the GLP-1 and stayed on this alone for 12 months, appetite held but weight barely moved 23:34
- chlorhex — the fullness effect hasnt faded over 26 months, unlike my semaglutide appetite curve 23:40
- group_buy_gwen — the fullness thing is the part people describe differently, food stops being interesting rather than repellent 23:53
is there a reason people titrate this over more weeks than the others
lost 68lb over 8 months on the combination and i genuinely cannot apportion it
cagrisema thats it
ok so nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
underwhelming honestly
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
held mine a while
i keep the two on separate days so if something goes wrong i have a chance of knowing which
the nausea felt different rather than less, more fullness and less of the queasy wave
[edited]stopped for 11 months and the fullness went within a fortnight of the last dose
❤️3✅4🔥4
held at 1.7 for 8 months on monotherapy before i touched it again, we shall see
slightly off topic but dropped the GLP-1 and stayed on this alone for 12 months, appetite held but weight barely moved
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
dosing them on different days made no difference i could detect
the fullness effect hasnt faded over 26 months, unlike my semaglutide appetite curve
🙏12📉1
monotherapy here
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
combination for me