slower than the others
#cagrilintide 2026-06-08
Monday28 messages6 participantstimes are UTC
Highlights from this day
- nadia_notes — did anyone find monotherapy underwhelming 20:58
- two_three_lifts — weekly for me, same day every week, no reason beyond habit 22:24
- verify_or_dont — unrelated but anyone dosing this on a different day to their tirzepatide 22:25
- verify_or_dont — the nausea felt different rather than less, more fullness and less of the queasy wave 22:46
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
amylin not glp-1
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5 in 3ml gives 2.5mg/ml which is what i use, purely because the units come out round
i titrated over twice as many weeks as i did on semaglutide and that was right for me
different not less
separate days
added it to an existing cagrilintide dose rather than starting both, which made attribution possible
is anyone running this on its own or is it all CagriSema in here
went slower because the first step gave me two rough days and i took that as information
did anyone find monotherapy underwhelming
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underwhelming honestly
dosing them on different days made no difference i could detect
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
update on the earlier thing amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
anyone stopped the GLP-1 and kept only this
combination GI was worse than either alone for me, which is not what i had read anywhere
cagrisema thats it
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monotherapy was underwhelming for me and i say that as someone who wanted it to work
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
cant separate them
does amylin do something about fullness that the GLP-1 doesnt
has REDEFINE reported or are people quoting earlier work
weekly for me, same day every week, no reason beyond habit
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unrelated but anyone dosing this on a different day to their tirzepatide
the nausea felt different rather than less, more fullness and less of the queasy wave
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how slow are people titrating this compared to retatrutide
i was sceptical about monotherapy and after 4 months im still sceptical, just less so