titrating dead slow
#cagrilintide 2026-05-18
Monday13 messages3 participantstimes are UTC
Highlights from this day
- noct.titrate — amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist 12:37
- elm_escalates — the fullness effect hasnt faded over 14 months, unlike my semaglutide appetite curve 13:05
- sasha_stacks — i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something 13:31
went slower because the first step gave me two rough days and i took that as information, ymmv
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
combination GI was worse than either alone for me, which is not what i had read anywhere
the fullness effect hasnt faded over 14 months, unlike my semaglutide appetite curve
📉6
does the fullness effect fade the way appetite suppression does
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
quick one stopped for 19 months and the fullness went within a fortnight of the last dose
is the combination just the two dosed together or a single formulation
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
ok so noticed something around week 4 on monotherapy, well after i had given up expecting to
thats the phase 3 one
monotherapy was underwhelming for me and i say that as someone who wanted it to work, thats just me