i titrated over twice as many weeks as i did on semaglutide and that was right for me
#cagrilintide 2026-05-08
Friday30 messages6 participantstimes are UTC
Highlights from this day
cant separate them
monotherapy did work for me, just slower and smaller than i expected
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slower than the others
anyone dosing this on a different day to their cagrilintide
titrating dead slow
did anyone add this to an existing cagrilintide dose rather than starting both
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
is the slower titration because of nausea or something else
is the weekly schedule the same here
pinch_not_stretchi titrated over twice as many weeks as i did on semaglutide and that was right for me
anyone stopped the GLP-1 and kept only this
lot-log.csv
490 rows · not retained in the public archive
has REDEFINE reported or are people quoting earlier work
[edited]held mine a while
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amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist, anyway
weekly for me, same day every week, no reason beyond habit
*week 11 not week 5
ok so is the combination just the two dosed together or a single formulation
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
pinch_not_stretchi titrated over twice as many weeks as i did on semaglutide and that was right for me
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
did the combination change your GI compared to the GLP-1 alone
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
anyone holding at 2.5 for a while before stepping
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lost 59lb over 9 months on the combination and i genuinely cannot apportion it
stopped for 12 months and the fullness went within a fortnight of the last dose
combination GI was worse than either alone for me, which is not what i had read anywhere
the fullness effect hasnt faded over 22 months, unlike my semaglutide appetite curve
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its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake, still working it out
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the fullness thing is the part people describe differently, food stops being interesting rather than repellent, we shall see
slightly off topic but whats REDEFINE testing exactly
amylin not glp-1
held at 1.7 for 3 months on monotherapy before i touched it again