is anyone running this on its own or is it all CagriSema in here
#cagrilintide 2026-05-04
Monday45 messages11 participantstimes are UTC
Highlights from this day
- sharps_comedy — monotherapy did work for me, just slower and smaller than i expected 20:25
- sarcopenia_sam — does the fullness effect fade the way appetite suppression does 21:04
- ida_injects — weekly for me, same day every week, no reason beyond habit, i think 21:09
- tam_logs — slightly off topic but anyone got two VendorInvestigate results on the same SWB lot for this 21:57
- VialBot — Reminder for sharps_bin_sid: dose day is today. Set 6 days ago. 23:27
monotherapy question, did appetite move for you without a GLP-1 alongside
monotherapy did work for me, just slower and smaller than i expected
weights-monthly.csv
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i was sceptical about monotherapy and after 23 months im still sceptical, just less so
sorry to jump in the fullness effect hasnt faded over 3 months, unlike my semaglutide appetite curve, we shall see
went slower because the first step gave me two rough days and i took that as information
how slow are people titrating this compared to cagrilintide
is the slower titration because of nausea or something else
sorry to jump in the reason nausea reads differently is timing, mine arrived on the second day rather than the first
two Medutest results on the same MKM lot came back 98.6 and 99.2, closer than i expected
anyone stopped the GLP-1 and kept only this
i titrated over twice as many weeks as i did on semaglutide and that was right for me, still working it out
dosing them on different days made no difference i could detect
underwhelming honestly
titrating dead slow
cagrisema thats it
[edited]does the fullness effect fade the way appetite suppression does
fullness rather than nausea
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weekly for me, same day every week, no reason beyond habit, i think
whats REDEFINE testing exactly
cant separate them
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i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
amylin not glp-1
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whats the recon people use, 2 in 1.5ml
did the combination change your GI compared to the GLP-1 alone
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
REDEFINE is the trial
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the slower titration in here is community habit as much as anything, the trials had their own schedule
is the weekly schedule the same here
anyone holding at 7.5 for a while before stepping
combination for me
slightly off topic but anyone got two VendorInvestigate results on the same SWB lot for this
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genuine question anyone dosing this on a different day to their retatrutide
is the combination just the two dosed together or a single formulation
monotherapy was underwhelming for me and i say that as someone who wanted it to work
combination GI was worse than either alone for me, which is not what i had read anywhere
Digest for the week of 2025-12-26 has been published.
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
unrelated but 20 in 2.5ml gives 8mg/ml which is what i use, purely because the units come out round
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back after 6 months, is monotherapy still a minority thing here
the nausea felt different rather than less, more fullness and less of the queasy wave
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amylin analogue, so its not a GLP-1 at all right
different not less
does amylin do something about fullness that the GLP-1 doesnt
Reminder for sharps_bin_sid: dose day is today. Set 6 days ago.
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CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it, i have it written down somewhere