held at 12 for 8 months on monotherapy before i touched it again
#cagrilintide 2026-04-30
Thursday52 messages13 participantstimes are UTC
Highlights from this day
- olive_orders — has REDEFINE reported or are people quoting earlier work 19:21
- rezept_rolf — changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, ill dig out the number 19:30
- rezept_rolf — i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something, n of 1 obviously 21:36
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
[edited]stopped for 14 months and the fullness went within a fortnight of the last dose
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
is there a reason people titrate this over more weeks than the others
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thats the phase 3 one
fridge-temps.csv
306 rows · not retained in the public archive
does the fullness effect fade the way appetite suppression does
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
is the slower titration because of nausea or something else
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
held mine a while
i titrated over twice as many weeks as i did on semaglutide and that was right for me
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has REDEFINE reported or are people quoting earlier work
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changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, ill dig out the number
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the reason nausea reads differently is timing, mine arrived on the second day rather than the first
dosing them on different days made no difference i could detect
REDEFINE is the trial
did the nausea feel different to you or just less
amylin not glp-1
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went slower because the first step gave me two rough days and i took that as information
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follow up combination GI was worse than either alone for me, which is not what i had read anywhere
the nausea felt different rather than less, more fullness and less of the queasy wave
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
cagrisema thats it
Purity check: no report on file for lot SG-1177. Nothing logged either way.
i keep the two on separate days so if something goes wrong i have a chance of knowing which
slower than the others
for the archive monotherapy was underwhelming for me and i say that as someone who wanted it to work
the fullness thing is the part people describe differently, food stops being interesting rather than repellent, from memory
[edited]different not less
combination for me
fullness rather than nausea
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20:42quiet.hours pinned a message
is the combination just the two dosed together or a single formulation
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
monotherapy here
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dosing them on different days made no difference i could detect
dropped the GLP-1 and stayed on this alone for 21 months, appetite held but weight barely moved
30 in 3ml gives 10mg/ml which is what i use, purely because the units come out round
underwhelming honestly
anyone stopped the GLP-1 and kept only this
separate days
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something, n of 1 obviously
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cant separate them
weekly for me, same day every week, no reason beyond habit
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
the slower titration in here is community habit as much as anything, the trials had their own schedule
how many weeks before you noticed anything on monotherapy
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
lost 103lb over 11 months on the combination and i genuinely cannot apportion it
separate days
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anyone dosing this on a different day to their semaglutide
is the nausea profile genuinely different or am i imagining it