went slower because the first step gave me two rough days and i took that as information, still working it out
#cagrilintide 2026-04-26
Sunday21 messages6 participantstimes are UTC
Highlights from this day
- assay_not_purity — did the combination change your GI compared to the GLP-1 alone 18:44
- bea_reconstitutes — the fullness thing is the part people describe differently, food stops being interesting rather than repellent, i think 19:34
- bea_reconstitutes — is the combination just the two dosed together or a single formulation 19:37
- apnoea_down_two — its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake 20:16
- customs_owl — amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist 20:17
genuine question is the nausea profile genuinely different or am i imagining it
anyone stopped the GLP-1 and kept only this
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
monotherapy question, did appetite move for you without a GLP-1 alongside
did the combination change your GI compared to the GLP-1 alone
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the fullness effect hasnt faded over 14 months, unlike my semaglutide appetite curve
slower than the others
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cant separate them
the fullness thing is the part people describe differently, food stops being interesting rather than repellent, i think
is the combination just the two dosed together or a single formulation
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did the nausea feel different to you or just less
weekly for me, same day every week, no reason beyond habit
different not less
right so whats REDEFINE testing exactly
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
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assay_not_puritythe fullness effect hasnt faded over 14 months, unlike my semaglutide appetite curve
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
amylin analogue, so its not a GLP-1 at all right
€185 for a 30 vial and it lasts me longer than the GLP-1 does at my doses
the slower titration in here is community habit as much as anything, the trials had their own schedule
noticed something around week 19 on monotherapy, well after i had given up expecting to