genuine question is the weekly schedule the same here
#cagrilintide 2025-12-18
Thursday36 messages7 participantstimes are UTC
Highlights from this day
anyone got two Janoshik results on the same HJ lot for this
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
combination GI was worse than either alone for me, which is not what i had read anywhere
REDEFINE is the trial
the slower titration in here is community habit as much as anything, the trials had their own schedule, thats just me
is the slower titration because of nausea or something else
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noticed something around week 26 on monotherapy, well after i had given up expecting to
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CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
weekly for me, same day every week, no reason beyond habit
£120 for a 10 vial and it lasts me longer than the GLP-1 does at my doses, ill dig out the number
dropped the GLP-1 and stayed on this alone for 22 months, appetite held but weight barely moved
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titrating dead slow
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, ymmv
the nausea felt different rather than less, more fullness and less of the queasy wave, thats just me
dosing them on different days made no difference i could detect
i was sceptical about monotherapy and after 23 months im still sceptical, just less so
how many weeks before you noticed anything on monotherapy
[edited]slightly off topic but back after 19 months, is monotherapy still a minority thing here
genuine question lost 61lb over 2 months on the combination and i genuinely cannot apportion it
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
cagrisema thats it
monotherapy was underwhelming for me and i say that as someone who wanted it to work
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
monotherapy question, did appetite move for you without a GLP-1 alongside
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing, take that with a pinch of salt
update on the earlier thing did the combination change your GI compared to the GLP-1 alone
two Medutest results on the same CPC lot came back 97.4 and 99, closer than i expected
cant separate them
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underwhelming honestly
quick one did the nausea feel different to you or just less
held at 2.4 for 7 months on monotherapy before i touched it again
combination GI was worse than either alone for me, which is not what i had read anywhere
is there a reason people titrate this over more weeks than the others
thats the phase 3 one
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i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
combination for me
slower than the others