amylin analogue, so its not a GLP-1 at all right
#cagrilintide 2025-12-04
Thursday14 messages5 participantstimes are UTC
Highlights from this day
- VialBot — Digest for the week of 2025-05-08 has been published. 10:50
- VialBot — Inter-lab diff for lot E-2205: 99.4% vs 99.2%. Within expected range. 11:05
- juno_joins — the fullness thing is the part people describe differently, food stops being interesting rather than repellent 12:20
- fridge_thermo — dropped the GLP-1 and stayed on this alone for 6 months, appetite held but weight barely moved 12:34
- oli_orals — is the combination just the two dosed together or a single formulation 12:36
20 in 1ml gives 2mg/ml which is what i use, purely because the units come out round
Digest for the week of 2025-05-08 has been published.
REDEFINE is the trial
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
Inter-lab diff for lot E-2205: 99.4% vs 99.2%. Within expected range.
🎉18
is the nausea profile genuinely different or am i imagining it
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
the fullness effect hasnt faded over 6 months, unlike my semaglutide appetite curve
dropped the GLP-1 and stayed on this alone for 6 months, appetite held but weight barely moved
⚠️14
is the combination just the two dosed together or a single formulation
📉1🎉5⚠️3
stopped for 5 months and the fullness went within a fortnight of the last dose