did anyone find monotherapy underwhelming
#cagrilintide 2025-11-30
Sunday35 messages7 participantstimes are UTC
Highlights from this day
- step_one_sian — is there a reason people titrate this over more weeks than the others 16:21
- dose_down_dara — you cannot tell which of the two is doing what in a combination and i stopped pretending i could, take that with a pinch of salt CagriSema is cagrilintide with… 18:35
- gradient_greg — monotherapy did work for me, just slower and smaller than i expected 20:00
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
combination for me
whats the recon people use, 15 in 0.5ml
dosing them on different days made no difference i could detect
is there a reason people titrate this over more weeks than the others
🤝1🔥16
held at 1 for 2 months on monotherapy before i touched it again
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
🙏3🎉6⚠️4
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
👀1🧊1🙏1
for the archive the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
how many weeks before you noticed anything on monotherapy
monotherapy question, did appetite move for you without a GLP-1 alongside
🎉4🔥4
unrelated but weekly for me, same day every week, no reason beyond habit
anyone dosing this on a different day to their semaglutide
i was sceptical about monotherapy and after 11 months im still sceptical, just less so
🎉1💀10👍1
has REDEFINE reported or are people quoting earlier work
amylin analogue, so its not a GLP-1 at all right
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
monotherapy here
you cannot tell which of the two is doing what in a combination and i stopped pretending i could, take that with a pinch of salt
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
✅3🤝8
amylin not glp-1
cant separate them
is anyone running this on its own or is it all CagriSema in here
slower than the others
the slower titration in here is community habit as much as anything, the trials had their own schedule
monotherapy did work for me, just slower and smaller than i expected
🧪8📈11👀4
held mine a while
REDEFINE is the trial
i titrated over twice as many weeks as i did on semaglutide and that was right for me
underwhelming honestly
🧪1👀10✅2
different not less
anyone holding at 5 for a while before stepping