does amylin do something about fullness that the GLP-1 doesnt
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#cagrilintide 2025-11-22
Saturday32 messages9 participantstimes are UTC
Highlights from this day
- ferritin_fay — does amylin do something about fullness that the GLP-1 doesnt 21:47
- vienna_vial — the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair 22:14
- hiccup_hollis — i titrated over twice as many weeks as i did on semaglutide and that was right for me 22:20
- vienna_vial — monotherapy was underwhelming for me and i say that as someone who wanted it to work 22:25
€72 for a 15 vial and it lasts me longer than the GLP-1 does at my doses
unrelated but the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
combination GI was worse than either alone for me, which is not what i had read anywhere, your mileage will differ
held at 7.5 for 9 months on monotherapy before i touched it again
amylin not glp-1
has REDEFINE reported or are people quoting earlier work
lost 81lb over 1 months on the combination and i genuinely cannot apportion it, i have it written down somewhere
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake, from memory
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
coa-f-1330.pdf
1 page · 680 KB · not retained in the public archive
Inter-lab diff for lot G-0641: 96.8% vs 99.2%. Within expected range.
i titrated over twice as many weeks as i did on semaglutide and that was right for me
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i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
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monotherapy was underwhelming for me and i say that as someone who wanted it to work
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changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
the nausea felt different rather than less, more fullness and less of the queasy wave, n of 1 obviously
whats REDEFINE testing exactly
monotherapy here
the fullness effect hasnt faded over 18 months, unlike my semaglutide appetite curve
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added it to an existing retatrutide dose rather than starting both, which made attribution possible
REDEFINE is the trial
coming back to this weekly for me, same day every week, no reason beyond habit
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thats the phase 3 one
noticed something around week 27 on monotherapy, well after i had given up expecting to
genuine question did anyone add this to an existing cagrilintide dose rather than starting both
titrating dead slow
different not less
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15 in 0.5ml gives 2.5mg/ml which is what i use, purely because the units come out round, anyway
the slower titration in here is community habit as much as anything, the trials had their own schedule
underwhelming honestly
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is the nausea profile genuinely different or am i imagining it