sorry to jump in amylin analogue, so its not a GLP-1 at all right
#cagrilintide 2025-11-01
Saturday31 messages8 participantstimes are UTC
Highlights from this day
did anyone find monotherapy underwhelming
combination GI was worse than either alone for me, which is not what i had read anywhere
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
held mine a while
coming back to this anyone stopped the GLP-1 and kept only this
🎉14
combination for me
is the slower titration because of nausea or something else
cant separate them
underwhelming honestly
anyone got two Janoshik results on the same SSA lot for this
📈16
the nausea felt different rather than less, more fullness and less of the queasy wave
has REDEFINE reported or are people quoting earlier work
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake, happy to be corrected
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
held at 12 for 5 months on monotherapy before i touched it again
👍6🎉4
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
went slower because the first step gave me two rough days and i took that as information
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
weekly for me, same day every week, no reason beyond habit, still working it out
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way, someone check my working
separate days
does amylin do something about fullness that the GLP-1 doesnt
REDEFINE is the trial
monotherapy here
is the weekly schedule the same here
📉3🤝5🙏5
is there a reason people titrate this over more weeks than the others
added it to an existing retatrutide dose rather than starting both, which made attribution possible
ok so 15 in 2ml gives 5mg/ml which is what i use, purely because the units come out round, n of 1 obviously
monotherapy question, did appetite move for you without a GLP-1 alongside
while im here dosing them on different days made no difference i could detect
cagrisema thats it
dropped the GLP-1 and stayed on this alone for 17 months, appetite held but weight barely moved
5 in 3ml gives 5mg/ml which is what i use, purely because the units come out round