back after 16 months, is monotherapy still a minority thing here
#cagrilintide 2025-10-30
Thursday29 messages9 participantstimes are UTC
Highlights from this day
- abdo_two_inch — the fullness thing is the part people describe differently, food stops being interesting rather than repellent 18:16
- retention_time — added it to an existing retatrutide dose rather than starting both, which made attribution possible 19:07
- retention_time — the fullness effect hasnt faded over 17 months, unlike my semaglutide appetite curve 19:09
- VialBot — Digest for the week of 2025-05-29 has been published. 19:21
i was sceptical about monotherapy and after 14 months im still sceptical, just less so
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
quick one anyone stopped the GLP-1 and kept only this
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you cannot tell which of the two is doing what in a combination and i stopped pretending i could, someone check my working
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
lot-log.csv
495 rows · not retained in the public archive
whats the recon people use, 15 in 0.5ml
*0.5ml sorry
monotherapy was underwhelming for me and i say that as someone who wanted it to work, i could be wrong
held at 0.25 for 6 months on monotherapy before i touched it again
how many weeks before you noticed anything on monotherapy
Reminder set. I will post here in 6 days.
is the combination just the two dosed together or a single formulation
did anyone find monotherapy underwhelming
added it to an existing retatrutide dose rather than starting both, which made attribution possible
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the fullness effect hasnt faded over 17 months, unlike my semaglutide appetite curve
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anyone dosing this on a different day to their cagrilintide
janoshik-b-0114.pdf
2 pages · 514 KB · not retained in the public archive
Digest for the week of 2025-05-29 has been published.
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the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
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the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
titrating dead slow
is the nausea profile genuinely different or am i imagining it
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combination GI was worse than either alone for me, which is not what i had read anywhere
i titrated over twice as many weeks as i did on semaglutide and that was right for me
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dosing them on different days made no difference i could detect
monotherapy here
unrelated but nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
different not less
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right so 30 in 5ml gives 4mg/ml which is what i use, purely because the units come out round