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#cagrilintide 2025-10-12

Sunday26 messages6 participantstimes are UTC
Highlights from this day
  • VialBot — Digest for the week of 2024-12-06 has been published. 15:27
  • vat_on_import — changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing 16:09
  • chlorhex — 15 in 1ml gives 8mg/ml which is what i use, purely because the units come out round 16:55
VO

the fullness thing is the part people describe differently, food stops being interesting rather than repellent, we shall see

VB

Digest for the week of 2024-12-06 has been published.

👍9
VO

combination GI was worse than either alone for me, which is not what i had read anywhere

£38 for a 2 vial and it lasts me longer than the GLP-1 does at my doses, ask me again in a month

the slower titration in here is community habit as much as anything, the trials had their own schedule, for what its worth

slightly off topic but is the combination just the two dosed together or a single formulation

changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing

Cited study
Efficacy and Safety of Cagrilintide in Adults with Overweight or Obesity — Phase 2
The Lancet · 2021
Cagrilintide monotherapy, dose ranging. The combination trials came later.

has REDEFINE reported or are people quoting earlier work

CH

weekly for me, same day every week, no reason beyond habit

CH

15 in 1ml gives 8mg/ml which is what i use, purely because the units come out round

🙏6❤️16
CH

added it to an existing tirzepatide dose rather than starting both, which made attribution possible, anyway

cant separate them

if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way

dosing them on different days made no difference i could detect

held mine a while

HL

i was sceptical about monotherapy and after 16 months im still sceptical, just less so

AA

how slow are people titrating this compared to semaglutide

Cited study
Efficacy and Safety of Cagrilintide in Adults with Overweight or Obesity — Phase 2
The Lancet · 2021
Cagrilintide monotherapy, dose ranging. The combination trials came later.
AA

held at 1.7 for 6 months on monotherapy before i touched it again
monotherapy was underwhelming for me and i say that as someone who wanted it to work

[edited]
AA

the reason nausea reads differently is timing, mine arrived on the second day rather than the first