its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
#cagrilintide 2025-09-30
Tuesday33 messages7 participantstimes are UTC
Highlights from this day
- quiet_head_qi — changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing 20:17
- juno_joins — the fullness effect hasnt faded over 13 months, unlike my semaglutide appetite curve 20:22
- first_and_last_four — dosing them on different days made no difference i could detect, your mileage will differ 21:13
- knees_first — back after 14 months, is monotherapy still a minority thing here 21:34
- first_and_last_four — two PeptideMeter results on the same MKM lot came back 96.8 and 98.6, closer than i expected, from memory 22:01
is the weekly schedule the same here
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
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is the combination just the two dosed together or a single formulation
the fullness effect hasnt faded over 13 months, unlike my semaglutide appetite curve
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genuine question €72 for a 20 vial and it lasts me longer than the GLP-1 does at my doses
weekly for me, same day every week, no reason beyond habit
slightly off topic but amylin analogue, so its not a GLP-1 at all right
fullness rather than nausea
stopped for 16 months and the fullness went within a fortnight of the last dose, still working it out
i titrated over twice as many weeks as i did on semaglutide and that was right for me
update on the earlier thing is there a reason people titrate this over more weeks than the others
did anyone add this to an existing tirzepatide dose rather than starting both
combination GI was worse than either alone for me, which is not what i had read anywhere
[edited]REDEFINE is the trial
monotherapy did work for me, just slower and smaller than i expected, anyway
slower than the others
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dosing them on different days made no difference i could detect, your mileage will differ
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did the nausea feel different to you or just less
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
chain_of_custodycombination GI was worse than either alone for me, which is not what i had read anywhere
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
back after 14 months, is monotherapy still a minority thing here
separate days
monotherapy here
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quick one i titrated over twice as many weeks as i did on semaglutide and that was right for me
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
two PeptideMeter results on the same MKM lot came back 96.8 and 98.6, closer than i expected, from memory
how do people separate which of the two is doing what in a combination
titrating dead slow
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lost 46lb over 19 months on the combination and i genuinely cannot apportion it, happy to be corrected
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
the nausea felt different rather than less, more fullness and less of the queasy wave
underwhelming honestly