vialroom

#cagrilintide 2025-04-17

Thursday41 messages8 participantstimes are UTC
Highlights from this day
  • VialBot — Testing queue: 8 submissions open, 92 awaiting dispatch. 17:07
  • VialBot — On this day 3 years ago this channel logged 86 messages. 19:11
  • salt_bridge — nobody should copy my schedule, im describing it because people asked what a slow ramp looks like 19:31
  • salt_bridge — monotherapy question, did appetite move for you without a GLP-1 alongside 19:40
CC

stopped for 9 months and the fullness went within a fortnight of the last dose

AA

went slower because the first step gave me two rough days and i took that as information

SL

CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it

2 in 1.5ml gives 2.5mg/ml which is what i use, purely because the units come out round

AA

did the combination change your GI compared to the GLP-1 alone

*VendorInvestigate not the other one

if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way

VB

Testing queue: 8 submissions open, 92 awaiting dispatch.

QH

how do people separate which of the two is doing what in a combination

is anyone running this on its own or is it all CagriSema in here

QH

the nausea felt different rather than less, more fullness and less of the queasy wave

CO

the fullness thing is the part people describe differently, food stops being interesting rather than repellent

CO

the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing

thats the phase 3 one

VB

On this day 3 years ago this channel logged 86 messages.

CC

dropped the GLP-1 and stayed on this alone for 3 months, appetite held but weight barely moved

19:18chlorhex pinned a message
SB

does amylin do something about fullness that the GLP-1 doesnt

🧊1

fullness rather than nausea

underwhelming honestly

🔥13

nobody should copy my schedule, im describing it because people asked what a slow ramp looks like

😂101🙏11

combination GI was worse than either alone for me, which is not what i had read anywhere, anyway

is the nausea profile genuinely different or am i imagining it

CC

REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work

i keep the two on separate days so if something goes wrong i have a chance of knowing which

*Janoshik not the other one

SB

monotherapy question, did appetite move for you without a GLP-1 alongside

🔥11

*Medutest not the other one