vialroom

#vendor-talk 2024-10-30

Wednesday47 messages11 participantstimes are UTC
Highlights from this day
  • monoisotopic — if a vendor is 20 percent cheaper per mg and runs 12 percent light on fill, you saved 8 percent and bought more uncertainty 21:35
  • monoisotopic — five vials i have weighed myself this year, gross mass corrected for the stopper, so treat the deltas as rough 21:38
  • vial_ledger — underfills, slow support, one lot that came in at 94 and another at 99. that is a variance problem, not a crime 22:22
  • monoisotopic — depends entirely on what you are doing. the trial dose ladders are public and they are not vague 22:49
  • monoisotopic — if your vial is 14 percent light you are not on the rung you think you are on. that is the whole reason fill accuracy is a vendor question and not a pedantry question 22:50
MS

i asked for a non standard vial size and got it without a surcharge. that told me more than any certificate, i think

3🧊11💀12

do the arithmetic

WZ

nobody here gets paid to say anything about any supplier and the mods would end me if i did

WZ

how do you tell a synthesis house from somebody with a sticker printer

quoted lead time was 7 days, real one was 14. is that typical

FA

i have never had a problem i could not resolve with WXT, which is a low bar and a lot of suppliers fail it

🧊2

three orders no issues

📈1💀7
AD

ask who actually makes it. about a third of suppliers answer honestly and that answer is worth a lot

VL

i am going to say the unpopular thing. cheap per mg is a trap and people in here keep falling for it

VL

it is arithmetic that assumes the mg on the label is in the vial

MO

if a vendor is 20 percent cheaper per mg and runs 12 percent light on fill, you saved 8 percent and bought more uncertainty

MO

five vials i have weighed myself this year, gross mass corrected for the stopper, so treat the deltas as rough

VendorLabel mgMeasured mgDelta
Wuhan Wansheng108.6-14%
Wuhan Wansheng109.9-1%
Qingdao Sigma Chemical54.4-12%
JEEP Peptides1010.1+1%
JEEP Peptides109.8-2%
MO

the second WWB number is nearly perfect though. that is the point. their variance is wide, not their honesty

NS

Wuhan Wansheng have been fine for me on four orders. cheap, arrived, worked out on paper

i would not buy a single vial from them and stake anything on it though

MO

that is a reasonable position and it is not the same as calling them bad

VL

no. QSC gets the most mixed write ups in here of anyone and none of them are fraud

underfills, slow support, one lot that came in at 94 and another at 99. that is a variance problem, not a crime

MO

and their paperwork has always matched what i measured on purity. it is the mass that wanders

VL

WuXi TIDES. you will pay two to three times per mg and you will get exactly what the sheet says every time

GG

for gram scale. which most people in here are not buying

VL

we agree on the facts and not on the conclusion, which is the normal state of this channel

MM

leaving it unresolved, it is a genuine disagreement not a fight

MO

depends entirely on what you are doing. the trial dose ladders are public and they are not vague

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
NEJM · 2022
72-week trial, fixed escalation to 5/10/15mg weekly — the reference ladder people quote in here

if your vial is 14 percent light you are not on the rung you think you are on. that is the whole reason fill accuracy is a vendor question and not a pedantry question

NS

*four orders, five now, one landed yesterday. still no complaints from me