10 was enough
#tirzepatide 2025-06-16
Monday44 messages11 participantstimes are UTC
Highlights from this day
- mhra_unlicensed — did going from 15 semaglutide to 5 of this feel like a step down for anyone 22:44
- invoice_mismatch — 5 was where i first noticed it properly, 2.5 did almost nothing for me 22:51
- step_one_sian — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 23:01
- tenpence — 40 units of a 4 solution is a lot of volume and i check that one twice every single time 23:11
at 15 the GI came back for me, so my easier profile claim only applies below that, from memory
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
how did people handle the 2.5 to 5 jump
GIP plus GLP-1
📈9⚠️12
did anybody switch back to semaglutide after trying this
15 is the top
titrate slow
unrelated but the two compounds arent interchangeable week for week even if the effect ends up similar
checked the units twice
weights-monthly.csv
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start low anyway
quick one why does everyone talk about 7.5 and not 10
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
did anyone find the GI easier than semaglutide at an equivalent effect
right so anyone got a 8 recon they like for the 2 vials
right so 12 did nothing extra over 10 for me and that still holds a year later
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
easier gi for me
switched last year
no clean conversion
there is no clean conversion between the two, anyone giving you a ratio is guessing
did going from 15 semaglutide to 5 of this feel like a step down for anyone
✅16💀15
coming back to this is SURMOUNT-OSA the sleep apnoea one
slightly off topic but at 12 my appetite is gone entirely, did anyone go down rather than up
folklore probably
5 was where i first noticed it properly, 2.5 did almost nothing for me
🤝15👍9🧪18
SURMOUNT is weight
if youre coming off semaglutide the honest answer is start low and find out, theres no table
is there a reason to titrate slower than the four week schedule
for the archive the GI difference held for me right up to 15, which isnt what a couple of people here found, ask me again in a month
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
🧊4✅3🔥15
the sweet spot thing is survivorship, the people it worked for stayed and said so, happy to be corrected
follow up is the 10 vial the common one or do people use 30
the sweet spot argument is really about effect per side effect, not a magic number
40 units of a 4 solution is a lot of volume and i check that one twice every single time
[edited]😂15📈5❤️7
the 10 vial in 5ml gives 10mg/ml which puts 2 on 20 units, nice round numbers
[edited]GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
coming off semaglutide, is there a conversion or do i restart at 2.5
🧊3🧪3⚠️9
switched from 5 semaglutide and started at 2.5, took the slow route, never regretted it
same plateau here
👍1🙏18⚠️13
5 did nothing
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the trials titrated every four weeks to a target, most people here stop at whatever works
unrelated but i argued the sweet spot was nonsense and then spent 24 months at 7.5 not needing more
whats the top licensed dose, 15 or does it go higher