no gap when i switched, took the last semaglutide dose and started this a week later
#tirzepatide 2025-06-01
Sunday38 messages7 participantstimes are UTC
Highlights from this day
- two_ml_two — the 2.5 to 5 step was the roughest one for me and everything after was easier 10:21
- VialBot — Channel stats, last 30 days: 39 messages from 32 members. 11:07
- typosquat_tay — if youre coming off semaglutide the honest answer is start low and find out, theres no table 11:09
- typosquat_tay — why does everyone talk about 7.5 and not 10 12:02
- typosquat_tay — changed my mind about needing 15, i was chasing a number rather than an outcome, thats just me 12:48
whats the top licensed dose, 15 or does it go higher
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
anyone tracked whether the GI difference held at the top doses
the 2.5 to 5 step was the roughest one for me and everything after was easier
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
restarted at 2.5 after 24 months off and the first two doses reminded me why titration exists
SURMOUNT is weight
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the GI difference held for me right up to 15, which isnt what a couple of people here found
12 did nothing extra over 10 for me and that still holds a year later, from memory
*that should say weekly
did anybody switch back to semaglutide after trying this
switched last year
at 1.7 my appetite is gone entirely, did anyone go down rather than up
titrate slow
i went to 15 and came back to 10, more suppression wasnt more useful for me
did going from 12 semaglutide to 5 of this feel like a step down for anyone
Channel stats, last 30 days: 39 messages from 32 members.
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
🎉7
5 did nothing
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
update on the earlier thing plateaued at 9 weeks the same way i did on semaglutide, so i doubt its compound specific, we shall see
went back to semaglutide after 9 months because the cost difference mattered more than the GI
how did people handle the 2.5 to 5 jump
same plateau here
easier gi for me
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
why does everyone talk about 7.5 and not 10
40 units of a 5 solution is a lot of volume and i check that one twice every single time
start low anyway
does the appetite effect feel different or just stronger
does the GIP arm actually explain the easier nausea or is that hand waving
7.5 gang
€55 for a 15 vial is roughly what ive paid for the last year
my VendorInvestigate result on a TFC vial came in at 96.8 which is why i keep buying from them
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
the trials titrated every four weeks to a target, most people here stop at whatever works
is 7.5 really the sweet spot or is that just channel folklore
changed my mind about needing 15, i was chasing a number rather than an outcome, thats just me
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did anyone find the GI easier than semaglutide at an equivalent effect