vialroom

#tirzepatide 2025-05-07

Wednesday28 messages8 participantstimes are UTC
Highlights from this day
  • pioneer_pia — is the 20 vial the common one or do people use 30 20:07
  • pioneer_pia — changed my mind about needing 15, i was chasing a number rather than an outcome 20:30
  • cold_chain_cmdr — for the archive the trials titrated every four weeks to a target, most people here stop at whatever works 20:48
CC

follow up 40 units of a 4 solution is a lot of volume and i check that one twice every single time, i could be wrong

PP

while im here is the sweet spot argument about effect or about side effects

CC

at 2.5 my appetite went completely and i dropped back a step, eating nothing isnt a win

whats the top licensed dose, 15 or does it go higher

PP

the 30 vial in 1.5ml gives 2mg/ml which puts 10 on 10 units, nice round numbers

PP

is the 20 vial the common one or do people use 30

😂16👍6❤️1
PP

the GI difference held for me right up to 15, which isnt what a couple of people here found

PP

changed my mind about needing 15, i was chasing a number rather than an outcome

janoshik-a-2601.pdf
2 pages · 496 KB · not retained in the public archive

does the GIP arm actually explain the easier nausea or is that hand waving

CC

for the archive the trials titrated every four weeks to a target, most people here stop at whatever works

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.
🎉154
CC

genuine question 12 did nothing extra over 10 for me and that still holds a year later

€240 for a 5 vial is roughly what ive paid for the last year

same plateau here

5 did nothing

🤝16
CC

the sweet spot thing is survivorship, the people it worked for stayed and said so

📈1

restarted at 2.5 after 18 months off and the first two doses reminded me why titration exists

BB

i argued the sweet spot was nonsense and then spent 16 months at 7.5 not needing more

CC

the two compounds arent interchangeable week for week even if the effect ends up similar

DD

the switch felt like a step down at first and then caught up around week 25

DD

sorry to jump in SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up