#tirzepatide 2025-04-04

Friday23 messages6 participantstimes are UTC

Highlights from this day

seven_five_sweet — unrelated but restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists my PeptideMeter result on a SSA vial came in at 98.1 which… 23:25
seven_five_sweet — held 10 for 25 months and lost 41kg over that stretch, slow and boring and fine 5 was where i first noticed it properly, 2.5 did almost nothing for me 23:29
seven_five_sweet — SURMOUNT-1 versus SURPASS-2, which one was the weight trial 23:31
void_volume — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 23:37
courier_vs_post — there is no clean conversion between the two, anyone giving you a ratio is guessing, i think 23:48

private_script_pri 23:06

is the sweet spot argument about effect or about side effects

how did people handle the 2.5 to 5 jump

is SURMOUNT-OSA the sleep apnoea one

GIP plus GLP-1

luerlok 23:13

coming off semaglutide, is there a conversion or do i restart at 2.5

private_script_pri 23:15

7.5 gang

seven_five_sweet 23:17

start low anyway

⚠️1😂13🙏1

void_volumelab23:19

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

does switching from semaglutide need a gap or do you just start

whats the plateau pattern here, same as semaglutide or different

[edited]

seven_five_sweet 23:25

unrelated but restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists
my PeptideMeter result on a SSA vial came in at 98.1 which is why i keep buying from them

🎉4📈4

*2ml not 2.5

held 10 for 25 months and lost 41kg over that stretch, slow and boring and fine
5 was where i first noticed it properly, 2.5 did almost nothing for me

unrelated but the 2.5 to 5 step was the roughest one for me and everything after was easier

SURMOUNT-1 versus SURPASS-2, which one was the weight trial

🙏3

void_volumelab23:32

SURMOUNT is weight

👀5

ruo_only 23:35

5 did nothing

void_volumelab23:37

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

seven_five_sweet *2ml not 2.5

void_volumelab23:42

did anybody switch back to semaglutide after trying this

ruo_only 23:43

i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from

void_volumelab23:45

15 is the top

courier_vs_post 23:48

there is no clean conversion between the two, anyone giving you a ratio is guessing, i think

❤️18😂8👀14

courier_vs_post 23:58

*Medutest not the other one