at 15 the GI came back for me, so my easier profile claim only applies below that
#tirzepatide 2025-04-01
Tuesday27 messages7 participantstimes are UTC
Highlights from this day
- rotate_the_site — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 19:11
- identity_shift — at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win 19:33
- identity_shift — does switching from semaglutide need a gap or do you just start 19:36
- freeze_thaw — restarted at 2.5 after 20 months off and the first two doses reminded me why titration exists i argued the sweet spot was nonsense and then spent 2 months at 7.5 not… 19:59
- oasis_ola — SURMOUNT-1 versus SURPASS-2, which one was the weight trial 21:02
40 units of a 4 solution is a lot of volume and i check that one twice every single time
im at 2.4 and thinking about 2, did anyone gain anything from that step
switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it
how long before the dual thing was noticeable to you
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
fridge-temps.csv
187 rows · not retained in the public archive
sorry to jump in there is no clean conversion between the two, anyone giving you a ratio is guessing
at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
🧊4
does switching from semaglutide need a gap or do you just start
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
👍1📈5
ok so 5 was where i first noticed it properly, 2.5 did almost nothing for me
update on the earlier thing the sweet spot thing is survivorship, the people it worked for stayed and said so
changed my mind about needing 15, i was chasing a number rather than an outcome
restarted at 2.5 after 20 months off and the first two doses reminded me why titration exists
i argued the sweet spot was nonsense and then spent 2 months at 7.5 not needing more
the trials titrated every four weeks to a target, most people here stop at whatever works
5 did nothing
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
coming off semaglutide, is there a conversion or do i restart at 2.5
held 10 for 14 months and lost 27kg over that stretch, slow and boring and fine
no gap when i switched, took the last semaglutide dose and started this a week later, thats one data point
folklore probably
12 did nothing extra over 10 for me and that still holds a year later
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
🎉4
is there a reason to titrate slower than the four week schedule
10 was enough
whats the plateau pattern here, same as semaglutide or different