switched last year
#tirzepatide 2025-03-14
Friday37 messages10 participantstimes are UTC
Highlights from this day
- no_appetite_nia — my PeptideMeter result on a QYB vial came in at 96.8 which is why i keep buying from them 10:56
- cat_on_the_tray — changed my mind about needing 15, i was chasing a number rather than an outcome 13:01
- two_four_ceiling — there is no clean conversion between the two, anyone giving you a ratio is guessing 13:40
- two_four_ceiling — i went to 15 and came back to 10, more suppression wasnt more useful for me 13:43
5 was where i first noticed it properly, 2.5 did almost nothing for me
how did people handle the 2.5 to 5 jump
the GI difference held for me right up to 15, which isnt what a couple of people here found
my PeptideMeter result on a QYB vial came in at 96.8 which is why i keep buying from them
checked the units twice
back after 23 months, do i restart at 2.5 or pick up near where i left off
Batch lookup E-2205: 9 independent reports on file, earliest 2024-10-01.
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
the sweet spot thing is survivorship, the people it worked for stayed and said so
no clean conversion
follow up does the GIP arm actually explain the easier nausea or is that hand waving
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
15 is the top
easier gi for me
is there a reason to titrate slower than the four week schedule
the sweet spot argument is really about effect per side effect, not a magic number, for what its worth
start low anyway
coming off semaglutide, is there a conversion or do i restart at 2.5
the trials titrated every four weeks to a target, most people here stop at whatever works
changed my mind about needing 15, i was chasing a number rather than an outcome
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40 units of a 2 solution is a lot of volume and i check that one twice every single time
[edited]anyone tracked whether the GI difference held at the top doses
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i argued the sweet spot was nonsense and then spent 26 months at 7.5 not needing more, i could be wrong
anyone stopped at 10 and stayed there for months
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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there is no clean conversion between the two, anyone giving you a ratio is guessing
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)i went to 15 and came back to 10, more suppression wasnt more useful for me
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at 15 the GI came back for me, so my easier profile claim only applies below that
SURMOUNT is weight
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, happy to be corrected
GIP plus GLP-1
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)10 was enough
titrate slow
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12 did nothing extra over 10 for me and that still holds a year later