#tirzepatide 2025-03-01

Saturday24 messages7 participantstimes are UTC

Highlights from this day

ring_size_down — does the appetite effect feel different or just stronger 23:06
non_scale_win — does the GIP arm actually explain the easier nausea or is that hand waving 23:20
unsolicited_dm — coming back to this 5 was where i first noticed it properly, 2.5 did almost nothing for me 23:26

the 2 vial in 2.5ml gives 5mg/ml which puts 2.5 on 10 units, nice round numbers

On this day 9 years ago this channel logged 107 messages.

does the appetite effect feel different or just stronger

Cited study

Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)

New England Journal of Medicine · 2024

AHI as the primary endpoint, with and without PAP therapy.

anyone stopped at 10 and stayed there for months

the switch felt like a step down at first and then caught up around week 31

folklore probably

unrelated but if youre coming off semaglutide the honest answer is start low and find out, theres no table

no clean conversion

titrate slow

is there a reason to titrate slower than the four week schedule

does the GIP arm actually explain the easier nausea or is that hand waving

🤝13✅2

at 0.5 my appetite is gone entirely, did anyone go down rather than up

did anybody switch back to semaglutide after trying this
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

coming back to this 5 was where i first noticed it properly, 2.5 did almost nothing for me

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

7.5 gang

is the sweet spot argument about effect or about side effects

anyone tracked whether the GI difference held at the top doses

changed my mind about needing 15, i was chasing a number rather than an outcome

restarted at 2.5 after 15 months off and the first two doses reminded me why titration exists

Digest for the week of 2024-07-30 has been published.

40 units of a 10 solution is a lot of volume and i check that one twice every single time, anyway

plateaued at 15 weeks the same way i did on semaglutide, so i doubt its compound specific

anyone got a 4 recon they like for the 20 vials
i sat at 7.5 for 3 months and never needed more, which is where the folklore comes from

coming back to this went back to semaglutide after 15 months because the cost difference mattered more than the GI