coming back to this GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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#tirzepatide 2025-02-10
Monday27 messages7 participantstimes are UTC
Highlights from this day
- glow_no — coming back to this GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 14:56
- split_dose_sam — did anyone go past 15 and was there any point to it 16:17
- ms_ms_mira — if youre coming off semaglutide the honest answer is start low and find out, theres no table 17:34
did going from 2 semaglutide to 5 of this feel like a step down for anyone
12 did nothing extra over 10 for me and that still holds a year later
quick one at 2.5 my appetite is gone entirely, did anyone go down rather than up
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
anyone tracked whether the GI difference held at the top doses
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, take that with a pinch of salt
anyone got a 8 recon they like for the 15 vials
did anyone go past 15 and was there any point to it
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does switching from semaglutide need a gap or do you just start
$240 for a 30 vial is roughly what ive paid for the last year
5 was where i first noticed it properly, 2.5 did almost nothing for me
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
plateaued at 3 weeks the same way i did on semaglutide, so i doubt its compound specific
5 was where i first noticed it properly, 2.5 did almost nothing for me
ok so went back to semaglutide after 23 months because the cost difference mattered more than the GI, your mileage will differ
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win, your mileage will differ
the trials titrated every four weeks to a target, most people here stop at whatever works
titrate slow
checked the units twice
[edited]does the appetite effect feel different or just stronger
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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did anybody switch back to semaglutide after trying this
5 did nothing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
same plateau here
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SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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there is no clean conversion between the two, anyone giving you a ratio is guessing