easier gi for me
#tirzepatide 2025-01-30
Thursday50 messages11 participantstimes are UTC
Highlights from this day
- panel_before_after — right so SURMOUNT-1 versus SURPASS-2, which one was the weight trial 18:11
- monoisotopic — if youre coming off semaglutide the honest answer is start low and find out, theres no table 18:26
- monoisotopic — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, happy to be corrected 18:31
- apob_over_ldl — quick one restarted at 2.5 after 13 months off and the first two doses reminded me why titration exists 18:53
- provincial_pat — 40 units of a 2 solution is a lot of volume and i check that one twice every single time 20:25
10 was enough
switched last year
for the archive the sweet spot thing is survivorship, the people it worked for stayed and said so
slightly off topic but $94 for a 15 vial is roughly what ive paid for the last year, i think
switched from 1 semaglutide and started at 2.5, took the slow route, never regretted it
anyone tracked whether the GI difference held at the top doses
checked the units twice
does the GIP arm actually explain the easier nausea or is that hand waving
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
whats the plateau pattern here, same as semaglutide or different
the 2.5 to 5 step was the roughest one for me and everything after was easier
folklore probably
GIP plus GLP-1
the switch felt like a step down at first and then caught up around week 3
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
5 did nothing
at 15 the GI came back for me, so my easier profile claim only applies below that
👍1🙏9
Assay note: SWB lot D-0718 reported at 98.6% of label content.
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
7.5 gang
coming back to this changed my mind about needing 15, i was chasing a number rather than an outcome
right so SURMOUNT-1 versus SURPASS-2, which one was the weight trial
😂18👍14⚠️13
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
15 is the top
🧊5
if youre coming off semaglutide the honest answer is start low and find out, theres no table
🧊5💀15
*Janoshik not the other one
no clean conversion
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, happy to be corrected
🙏8🧪10
follow up there is no clean conversion between the two, anyone giving you a ratio is guessing
12 did nothing extra over 10 for me and that still holds a year later
update on the earlier thing i sat at 7.5 for 16 months and never needed more, which is where the folklore comes from
[edited]quick one restarted at 2.5 after 13 months off and the first two doses reminded me why titration exists
🙏13❤️16
anyone stopped at 10 and stayed there for months
SURMOUNT is weight
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
held 10 for 13 months and lost 35kg over that stretch, slow and boring and fine
✅2👍1📈14
slightly off topic but the sweet spot argument is really about effect per side effect, not a magic number
anyone got a 4 recon they like for the 2 vials
i argued the sweet spot was nonsense and then spent 7 months at 7.5 not needing more
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, n of 1 obviously
back after 5 months, do i restart at 2.5 or pick up near where i left off
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
🔥1📉7
went back to semaglutide after 18 months because the cost difference mattered more than the GI
start low anyway
🧊18📉1
the 40 vial in 2.5ml gives 4mg/ml which puts 2 on 8 units, nice round numbers
how did people handle the 2.5 to 5 jump
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
plateaued at 24 weeks the same way i did on semaglutide, so i doubt its compound specific
40 units of a 2 solution is a lot of volume and i check that one twice every single time
💀15🧪7📉5
the trials titrated every four weeks to a target, most people here stop at whatever works