is SURMOUNT-OSA the sleep apnoea one
#tirzepatide 2025-01-10
Friday36 messages8 participantstimes are UTC
Highlights from this day
- mag_citrate — does switching from semaglutide need a gap or do you just start 17:59
- protein_floor — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, i think 19:17
- protein_floor — i log everything and my appetite curve looks flatter across the week than my semaglutide log did 19:33
- HPLC_Hank — follow up anyone stopped at 10 and stayed there for months 21:18
does switching from semaglutide need a gap or do you just start
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
did anyone find the GI easier than semaglutide at an equivalent effect
12 did nothing extra over 10 for me and that still holds a year later
is there a reason to titrate slower than the four week schedule
*week 31 not week 3
checked the units twice
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anyone tracked whether the GI difference held at the top doses
quick one restarted at 2.5 after 11 months off and the first two doses reminded me why titration exists
15 is the top
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no clean conversion
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, i think
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held 10 for 21 months and lost 15kg over that stretch, slow and boring and fine, your mileage will differ
folklore probably
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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switched last year
is 7.5 really the sweet spot or is that just channel folklore
switched from 2 semaglutide and started at 2.5, took the slow route, never regretted it
at 15 the GI came back for me, so my easier profile claim only applies below that
Inter-lab diff for lot KP-0925: 98.6% vs 99.4%. Within expected range.
how did people handle the 2.5 to 5 jump
the GI difference held for me right up to 15, which isnt what a couple of people here found, ymmv
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
10 was enough
is the sweet spot argument about effect or about side effects
anyone got a 10 recon they like for the 40 vials
the switch felt like a step down at first and then caught up around week 34
easier gi for me
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no gap when i switched, took the last semaglutide dose and started this a week later
follow up anyone stopped at 10 and stayed there for months
transit-times.csv
712 rows · not retained in the public archive
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, i think
GIP plus GLP-1
the sweet spot argument is really about effect per side effect, not a magic number, i could be wrong
the trials titrated every four weeks to a target, most people here stop at whatever works
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7.5 gang
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