vialroom

#tirzepatide 2024-12-19

Thursday37 messages8 participantstimes are UTC
Highlights from this day
  • surpass_two — does switching from semaglutide need a gap or do you just start 17:55
  • vat_on_import — switched from 1 semaglutide and started at 2.5, took the slow route, never regretted it, ymmv the switch felt like a step down at first and then caught up around week… 18:00
  • vat_on_import — 5 was where i first noticed it properly, 2.5 did almost nothing for me, from memory 19:07
  • salt_bridge — if youre coming off semaglutide the honest answer is start low and find out, theres no table, i have it written down somewhere 20:16
TF

while im here licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does

AP

the two compounds arent interchangeable week for week even if the effect ends up similar, i could be wrong

5 did nothing

Cited study
Continued Treatment with Tirzepatide for Maintenance of Weight Reduction (SURMOUNT-4)
JAMA · 2024
Randomised withdrawal after a 36-week lead-in. Pairs with STEP 4.

did anyone go past 15 and was there any point to it

how did people handle the 2.5 to 5 jump

VO

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

held 10 for 14 months and lost 27kg over that stretch, slow and boring and fine

ST

the sweet spot argument is really about effect per side effect, not a magic number, ask me again in a month

40 units of a 5 solution is a lot of volume and i check that one twice every single time

at 1 my appetite is gone entirely, did anyone go down rather than up

easier gi for me

⚠️2🧪3🤝6

does switching from semaglutide need a gap or do you just start

🙏5
VO

switched from 1 semaglutide and started at 2.5, took the slow route, never regretted it, ymmv
the switch felt like a step down at first and then caught up around week 29

TO

10 was enough

lot-log.csv
617 rows · not retained in the public archive
VO

5 was where i first noticed it properly, 2.5 did almost nothing for me, from memory

📈12🧪1
VV

ok so whats the plateau pattern here, same as semaglutide or different

AP

at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win

12 did nothing extra over 10 for me and that still holds a year later

SB

the sweet spot thing is survivorship, the people it worked for stayed and said so

VV

does the GIP arm actually explain the easier nausea or is that hand waving

the switch felt like a step down at first and then caught up around week 24

went back to semaglutide after 2 months because the cost difference mattered more than the GI