SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
#tirzepatide 2024-11-28
Thursday36 messages7 participantstimes are UTC
Highlights from this day
- typosquat_tay — i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from 11:35
- assay_not_purity — the sweet spot argument is really about effect per side effect, not a magic number held 10 for 25 months and lost 10kg over that stretch, slow and boring and fine 12:04
- quiet_head_qi — €240 for a 2 vial is roughly what ive paid for the last year 13:54
- quiet_head_qi — genuine question the GI difference held for me right up to 15, which isnt what a couple of people here found 13:58
- quiet_head_qi — update on the earlier thing SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 14:06
is there a reason to titrate slower than the four week schedule
i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from
the trials titrated every four weeks to a target, most people here stop at whatever works
15 is the top
i went to 15 and came back to 10, more suppression wasnt more useful for me
the 2.5 to 5 step was the roughest one for me and everything after was easier
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
7.5 gang
[edited]wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)coming back to this at 15 the GI came back for me, so my easier profile claim only applies below that
is SURMOUNT-OSA the sleep apnoea one
GIP plus GLP-1
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the sweet spot argument is really about effect per side effect, not a magic number
held 10 for 25 months and lost 10kg over that stretch, slow and boring and fine
🧪5📈3👀17
did anyone find the GI easier than semaglutide at an equivalent effect
did anyone go past 15 and was there any point to it
coming off semaglutide, is there a conversion or do i restart at 2.5
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
the sweet spot thing is survivorship, the people it worked for stayed and said so
start low anyway
is the 20 vial the common one or do people use 5
€240 for a 2 vial is roughly what ive paid for the last year
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)*Medutest not the other one
genuine question the GI difference held for me right up to 15, which isnt what a couple of people here found
did anybody switch back to semaglutide after trying this
if youre coming off semaglutide the honest answer is start low and find out, theres no table
*Janoshik not the other one
update on the earlier thing SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
there is no clean conversion between the two, anyone giving you a ratio is guessing
plateaued at 12 weeks the same way i did on semaglutide, so i doubt its compound specific
while im here at 0.25 my appetite went completely and i dropped back a step, eating nothing isnt a win
easier gi for me
whats the top licensed dose, 15 or does it go higher
no gap when i switched, took the last semaglutide dose and started this a week later
40 units of a 8 solution is a lot of volume and i check that one twice every single time