went back to semaglutide after 14 months because the cost difference mattered more than the GI
#tirzepatide 2024-11-15
Friday44 messages8 participantstimes are UTC
Highlights from this day
- split_shipment — back after 6 months, do i restart at 2.5 or pick up near where i left off 06:32
- month_six_me — at 15 the GI came back for me, so my easier profile claim only applies below that 07:28
- pinch_not_stretch — i sat at 7.5 for 12 months and never needed more, which is where the folklore comes from 08:17
switched last year
the switch felt like a step down at first and then caught up around week 21
did anyone find the GI easier than semaglutide at an equivalent effect
10 was enough
held 10 for 2 months and lost 17kg over that stretch, slow and boring and fine
i went to 15 and came back to 10, more suppression wasnt more useful for me
does the appetite effect feel different or just stronger
12 did nothing extra over 10 for me and that still holds a year later
did anybody switch back to semaglutide after trying this
40 units of a 4 solution is a lot of volume and i check that one twice every single time
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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5 did nothing
apob_over_ldl40 units of a 4 solution is a lot of volume and i check that one twice every single time
is there a reason to titrate slower than the four week schedule
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restarted at 2.5 after 16 months off and the first two doses reminded me why titration exists, anyway
coming off semaglutide, is there a conversion or do i restart at 2.5
im at 7.5 and thinking about 0.25, did anyone gain anything from that step
back after 6 months, do i restart at 2.5 or pick up near where i left off
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
is SURMOUNT-OSA the sleep apnoea one
plateaued at 8 weeks the same way i did on semaglutide, so i doubt its compound specific
at 15 the GI came back for me, so my easier profile claim only applies below that
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anyone tracked whether the GI difference held at the top doses
split_shipmentrestarted at 2.5 after 16 months off and the first two doses reminded me why titration…
same plateau here
[edited]SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
does the GIP arm actually explain the easier nausea or is that hand waving
5 was where i first noticed it properly, 2.5 did almost nothing for me
is the 2 vial the common one or do people use 40
i sat at 7.5 for 12 months and never needed more, which is where the folklore comes from
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
anyone stopped at 10 and stayed there for months
genuine question the GI difference held for me right up to 15, which isnt what a couple of people here found
easier gi for me
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
genuine question how did people handle the 2.5 to 5 jump
the 2.5 to 5 step was the roughest one for me and everything after was easier
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
restarted at 2.5 after 25 months off and the first two doses reminded me why titration exists
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i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
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did anyone go past 15 and was there any point to it
GIP plus GLP-1
[edited]is 7.5 really the sweet spot or is that just channel folklore
the sweet spot thing is survivorship, the people it worked for stayed and said so
quick one did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
how many weeks at 7.5 before you knew it was enough
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