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#tirzepatide 2024-10-01

Tuesday19 messages4 participantstimes are UTC
Highlights from this day
  • baseline_drift — the sweet spot argument is really about effect per side effect, not a magic number 19:50
  • septum_sal — the 5 vial in 5ml gives 2.5mg/ml which puts 1 on 8 units, nice round numbers, not advice obviously if youre coming off semaglutide the honest answer is start low and… 19:56
  • hair_month_four — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 20:05

at 15 the GI came back for me, so my easier profile claim only applies below that

at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win

right so does switching from semaglutide need a gap or do you just start

the sweet spot thing is survivorship, the people it worked for stayed and said so

ST

slightly off topic but held 10 for 24 months and lost 15kg over that stretch, slow and boring and fine

SS

i sat at 7.5 for 11 months and never needed more, which is where the folklore comes from, thats one data point

SS

5 did nothing

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

15 is the top

BD

the sweet spot argument is really about effect per side effect, not a magic number

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SS

is the sweet spot argument about effect or about side effects

the 5 vial in 5ml gives 2.5mg/ml which puts 1 on 8 units, nice round numbers, not advice obviously
if youre coming off semaglutide the honest answer is start low and find out, theres no table

HM

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

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SS

40 units of a 5 solution is a lot of volume and i check that one twice every single time

[edited]
SS

dual agonist, GIP as well as GLP-1, thats the whole difference in one line, we shall see

whats the top licensed dose, 15 or does it go higher