vialroom

#tirzepatide 2024-09-06

Friday40 messages8 participantstimes are UTC
Highlights from this day
  • blind_submit — anyone got a 4 recon they like for the 40 vials 15:45
  • blind_submit — SURMOUNT-1 versus SURPASS-2, which one was the weight trial 16:02
  • ring_size_down — follow up 40 units of a 10 solution is a lot of volume and i check that one twice every single time 16:17
  • triumph_watch — is 7.5 really the sweet spot or is that just channel folklore 16:47
VB

Archive lookup: split_dose_sam first appears in this channel on 2024-07-13.

licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does

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changed my mind about needing 15, i was chasing a number rather than an outcome

Cited study
Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)
New England Journal of Medicine · 2024
AHI as the primary endpoint, with and without PAP therapy.

switched last year

GG

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, ill dig out the number

VB

Purity check: no report on file for lot B-0114. Nothing logged either way.

BS

right so the GI difference held for me right up to 15, which isnt what a couple of people here found

BS

SURMOUNT-1 versus SURPASS-2, which one was the weight trial

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RS

my Janoshik result on a SGN vial came in at 96.8 which is why i keep buying from them
i log everything and my appetite curve looks flatter across the week than my semaglutide log did

switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it

6
RS

follow up 40 units of a 10 solution is a lot of volume and i check that one twice every single time

Cited study
Continued Treatment with Tirzepatide for Maintenance of Weight Reduction (SURMOUNT-4)
JAMA · 2024
Randomised withdrawal after a 36-week lead-in. Pairs with STEP 4.
DD

im at 7.5 and thinking about 2, did anyone gain anything from that step
the trials titrated every four weeks to a target, most people here stop at whatever works

TW

is SURMOUNT-OSA the sleep apnoea one
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

held 10 for 11 months and lost 3kg over that stretch, slow and boring and fine

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is 7.5 really the sweet spot or is that just channel folklore

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DD

i went to 15 and came back to 10, more suppression wasnt more useful for me

SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up

GIP plus GLP-1

how did people handle the 2.5 to 5 jump

Cited study
Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)
New England Journal of Medicine · 2024
AHI as the primary endpoint, with and without PAP therapy.

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

GG

i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more

the two compounds arent interchangeable week for week even if the effect ends up similar

genuine question restarted at 2.5 after 8 months off and the first two doses reminded me why titration exists, your mileage will differ

HS

update on the earlier thing did going from 12 semaglutide to 5 of this feel like a step down for anyone

GG

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

GG

back after 10 months, do i restart at 2.5 or pick up near where i left off

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