the door swings four or five degrees every time somebody opens it. the back barely moves
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#storage-coldchain 2025-04-19
Saturday40 messages8 participantstimes are UTC
Highlights from this day
- septum_sal — while im here a cooler with two gel packs held under eight degrees for eleven hours on a drive 22:27
- septum_sal — i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why light exposure matters much less than temperature for… 22:28
- septum_sal — quick one if you are worried after a bad transit, test it. that is what the testing channels are for 22:38
- deamidation — i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine 23:21
unopened and in-use in the same place is fine. just keep the in-use one where you can reach it
the vial that visibly changed after a warm transit was the one that had already been reconstituted
i keep everything at the back of the middle shelf, never the door
unrelated but a few hours at room temperature is almost certainly nothing. a week is a different conversation
lyophilised at room temp for 23 days in transit, worried or not
buy a thermometer
hotel minibars are frequently not cold enough. i take a thermometer, which is ridiculous and also correct, ymmv
power cut with the door shut for a few hours is fine. a full fridge holds temperature surprisingly well
solution is not
gel packs
hand luggage
i would bin it
anyone had a vial visibly change after a warm transit
update from 22 months ago: replaced the fridge, temperature is stable, no more anxiety
while im here a cooler with two gel packs held under eight degrees for eleven hours on a drive
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i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why
light exposure matters much less than temperature for these. i still keep them in the carton
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what temperature does a domestic fridge door actually swing to
light exposure matters much less than temperature for these. i still keep them in the carton
[edited]| Condition | Lyophilised | Reconstituted |
|---|---|---|
| 2-8 °C | fine, long term | fine, weeks |
| Room temp, days | fine in every report here | reported fine, shorter |
| Room temp, weeks | reported fine | do not |
| Warm transit, 30 °C+ | no failure logged | one visible degradant peak |
| Frozen once | fine | contested, no consensus |
| Freeze-thaw cycled | fine | the room says no |
back of the fridge
[edited]nobody here can tell you a vial is safe. we can tell you what has and has not survived for us
quick one if you are worried after a bad transit, test it. that is what the testing channels are for
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buy a thermometer. mine reads 7.4 on the door and two degrees lower at the back
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
two to eight degrees. most domestic fridge doors are not in that range and people do not check, from memory
*that should say weekly
lyophilised powder is genuinely robust. a warm transit is far less likely to matter than people fear
my fridge is 5.6
not the freezer
power cut for 3 hours, fridge stayed shut, am i fine
the practical risk in winter shipping is freezing, and in summer it is heat. plan for the season you are in
*Medutest not the other one
right so anyone tested a vial before and after a bad transit
my fridge is running at 5.6, is that out of range
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
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i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why
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i log the fridge temperature daily and the room has never let me forget it
genuine question freeze debate again