does the amber vial thing matter or is it marketing
#storage-coldchain 2025-04-12
- cold_chain_cmdr — i have never had a lyophilised vial fail after a warm transit and i have had some bad ones 17:11
- cold_chain_cmdr — i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine 17:25
- plateau_pen — unopened and in-use in the same place is fine. just keep the in-use one where you can reach it 17:53
- plateau_pen — update on the earlier thing does the fridge in a hotel room count as a fridge a few hours at room temperature is almost certainly nothing. a week is a different… 18:24
hand luggage
the vial that visibly changed after a warm transit was the one that had already been reconstituted
a liquid cold pack tells you it was above freezing, not that your vial cooked, not advice obviously
i left it out overnight by accident, bin it or use it
back of the fridge
buy a thermometer
i have never had a lyophilised vial fail after a warm transit and i have had some bad ones
i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine
| Condition | Lyophilised | Reconstituted |
|---|---|---|
| 2-8 °C | fine, long term | fine, weeks |
| Room temp, days | fine in every report here | reported fine, shorter |
| Room temp, weeks | reported fine | do not |
| Warm transit, 30 °C+ | no failure logged | one visible degradant peak |
| Frozen once | fine | contested, no consensus |
| Freeze-thaw cycled | fine | the room says no |
slightly off topic but how long is reconstituted actually good for at room temperature
i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why
do i need to worry about light exposure or is that overthinking
Batch lookup F-1330: 7 independent reports on file, earliest 2024-07-20.
unopened and in-use in the same place is fine. just keep the in-use one where you can reach it
thats fine
update on the earlier thing does the fridge in a hotel room count as a fridge
a few hours at room temperature is almost certainly nothing. a week is a different conversation
*week 27 not week 8
freeze thaw cycling is the risk, not one freeze. that is my read of it anyway
the door swings four or five degrees every time somebody opens it. the back barely moves, i could be wrong
parcel sat in a hot mailbox for 4 hours, is it dead
| Condition | Lyophilised | Reconstituted |
|---|---|---|
| 2-8 °C | fine, long term | fine, weeks |
| Room temp, days | fine in every report here | reported fine, shorter |
| Room temp, weeks | reported fine | do not |
| Warm transit, 30 °C+ | no failure logged | one visible degradant peak |
| Frozen once | fine | contested, no consensus |
| Freeze-thaw cycled | fine | the room says no |
i keep everything at the back of the middle shelf, never the door
coming back to this lyophilised at room temp for 15 days in transit, worried or not
my fridge is running at 5.6, is that out of range
if you are worried after a bad transit, test it. that is what the testing channels are for, thats one data point