vialroom

#storage-coldchain 2025-04-12

Saturday24 messages7 participantstimes are UTC
Highlights from this day
  • cold_chain_cmdr — i have never had a lyophilised vial fail after a warm transit and i have had some bad ones 17:11
  • cold_chain_cmdr — i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine 17:25
  • plateau_pen — unopened and in-use in the same place is fine. just keep the in-use one where you can reach it 17:53
  • plateau_pen — update on the earlier thing does the fridge in a hotel room count as a fridge a few hours at room temperature is almost certainly nothing. a week is a different… 18:24
CC

the vial that visibly changed after a warm transit was the one that had already been reconstituted

SB

a liquid cold pack tells you it was above freezing, not that your vial cooked, not advice obviously

back of the fridge

buy a thermometer

CC

i have never had a lyophilised vial fail after a warm transit and i have had some bad ones

🔥9📉18
CC

i left a reconstituted vial out overnight once, sent it for testing out of curiosity, it came back fine

ConditionLyophilisedReconstituted
2-8 °Cfine, long termfine, weeks
Room temp, daysfine in every report herereported fine, shorter
Room temp, weeksreported finedo not
Warm transit, 30 °C+no failure loggedone visible degradant peak
Frozen oncefinecontested, no consensus
Freeze-thaw cycledfinethe room says no
🔥15

slightly off topic but how long is reconstituted actually good for at room temperature

🧊2👀1🔥12
HI

i freeze aliquots and have had them test fine afterwards. others here would not do it and i understand why

VB

Batch lookup F-1330: 7 independent reports on file, earliest 2024-07-20.

PP

unopened and in-use in the same place is fine. just keep the in-use one where you can reach it

13❤️8😂5

thats fine

PP

update on the earlier thing does the fridge in a hotel room count as a fridge
a few hours at room temperature is almost certainly nothing. a week is a different conversation

🙏18

*week 27 not week 8

freeze thaw cycling is the risk, not one freeze. that is my read of it anyway

HI

the door swings four or five degrees every time somebody opens it. the back barely moves, i could be wrong

parcel sat in a hot mailbox for 4 hours, is it dead

ConditionLyophilisedReconstituted
2-8 °Cfine, long termfine, weeks
Room temp, daysfine in every report herereported fine, shorter
Room temp, weeksreported finedo not
Warm transit, 30 °C+no failure loggedone visible degradant peak
Frozen oncefinecontested, no consensus
Freeze-thaw cycledfinethe room says no
4

i keep everything at the back of the middle shelf, never the door

BB

coming back to this lyophilised at room temp for 15 days in transit, worried or not