steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
#semaglutide 2026-06-28
Sunday76 messages13 participantstimes are UTC
Highlights from this day
- drawup_dee — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 15:21
- tarpit_tam — lost about 37kg on the low doses before i even got to 1, which surprised me, your mileage will differ 16:41
- kev_measures — did the STEP 4 withdrawal arm show what i think it showed SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial 17:00
- tarpit_tam — whats the actual licensed ceiling, i keep seeing different numbers 19:25
- kev_measures — restarted after 17 months off at a low dose and the nausea arrived exactly like the first time 20:32
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, i have it written down somewhere
[edited]going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, for what its worth
is 2.4 the top or do people go past it
went too fast once
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgfollow up compounded and brand felt the same to me at 1.7, which is one person and nothing more
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does the licensed ceiling for weight differ from the diabetes one
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose, i think
back after 23 months off, do i restart at 0.25 or somewhere higher
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
how long till steady state, ive read the half life is about a week
steady state takes weeks
i dont think the plateau is a dose problem most of the time, but i cant prove that
thats STEP 1
SELECT wasnt weight
10 months at 2.4 and the honest summary is diminishing returns after the first half
slower worked better
half life is about a week so youre roughly four to five weeks to steady state on any new dose
follow up went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
same dose day
is the plateau usually appetite coming back or just the scale stopping
held at 7.5 and lost 26lb over 5 months, slower than the trials and fine by me
lost about 37kg on the low doses before i even got to 1, which surprised me, your mileage will differ
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seven days ish
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my dose day drifted from friday to sunday, does that reset anything
did the STEP 4 withdrawal arm show what i think it showed
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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while im here im at 12 and stuck, did anyone break a plateau without going up
is there a reason to hold at 1.7 rather than going to 2.4
bac_water_billchanged my mind on the four week rule, i think it depends entirely on how the current…
five week steps worked better for me than four, purely on how the second week felt, ymmv
anyone gone from 15 straight to 0.5 or is that too big a jump
did anyone hold at 5 longer than four weeks before going up
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how many weeks before you noticed anything at 0.5
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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sorry to jump in anyone compared their 8 vial dosing against the pen increments
*PeptideMeter not the other one
my 30 vial in 1ml gives 10mg/ml so 2.5 lands on 12 units, thats why i picked that volume
i held at 5 for 4 months and it was the best decision i made
the long half life flattens the trough more than people expect, i never felt a day seven dip
how did people handle the jump from 1 to 1.7
was STEP 4 the one that ran to 68 weeks or am i mixing them up
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
£185 a month for compounded against what brand costs locally is why most people here use vials
mine faded too
brand vs compounded, is there a difference people can actually feel
plateaus move
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
[edited]2.4 is the ceiling
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
give it four weeks
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did anyone titrate slower than four weeks a step and how did that go
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
vial units and pen clicks are different systems, mixing the two is how people end up wrong
held there too
[edited]steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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how long did the first 14kg take for people at the low doses
vials not pens here
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgdose day is sunday for me only because thats when i remember, not because sunday matters
moving my dose day by a day or two never did anything noticeable for me
slightly off topic but i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it
the appetite effect faded for me around 4 months and going up fixed it for a while
not the same trial
my Medutest report on the SSA vial came back 99.4 against a certificate saying 98.1
seven days ish
does the seven day half life mean the last two days are weaker
[edited]whats the actual licensed ceiling, i keep seeing different numbers
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does anyone actually run a five week step instead of four
not the same trial
give it four weeks
steady state takes weeks
dose day is sunday for me only because thats when i remember, not because sunday matters
held there too
lost about 29kg on the low doses before i even got to 1, which surprised me
On this day 4 years ago this channel logged 112 messages.
STEP 1 ran to 68 weeks. thats the one everyone half remembers
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restarted after 17 months off at a low dose and the nausea arrived exactly like the first time
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