New independent result logged — QSC, lot A-2418, purity 99% (VendorInvestigate).
#semaglutide 2026-06-12
Friday47 messages11 participantstimes are UTC
Highlights from this day
- VialBot — New independent result logged — QSC, lot A-2418, purity 99% (VendorInvestigate). 18:24
- lot_number_lou — the appetite effect faded for me around 17 months and going up fixed it for a while 20:10
- fibre_first — five week steps worked better for me than four, purely on how the second week felt 20:40
- plus_sixteen — anyone gone from 2 straight to 0.25 or is that too big a jump licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose 21:38
does moving my dose day by two days matter with a seven day half life
slower worked better
Testing queue: 5 submissions open, 12 awaiting dispatch.
not the same trial
coming back to this held at 7.5 and lost 15lb over 19 months, slower than the trials and fine by me
lost about 41kg on the low doses before i even got to 1, which surprised me
compounded and brand felt the same to me at 7.5, which is one person and nothing more
brand vs compounded, is there a difference people can actually feel
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
STEP 1 ran to 68 weeks. thats the one everyone half remembers, someone check my working
for the archive if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
i held at 10 for 5 months and it was the best decision i made
[edited]STEP is several trials, so saying STEP said x is usually wrong without a number after it
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, from memory
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
On this day 4 years ago this channel logged 122 messages.
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, from memory
vial units and pen clicks are different systems, mixing the two is how people end up wrong
i dont think the plateau is a dose problem most of the time, but i cant prove that
😂1
the appetite effect faded for me around 17 months and going up fixed it for a while
👍9
give it four weeks
did the STEP 4 withdrawal arm show what i think it showed
is the plateau usually appetite coming back or just the scale stopping
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
plateaus move
the long half life flattens the trough more than people expect, i never felt a day seven dip, anyway
five week steps worked better for me than four, purely on how the second week felt
👍9
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
held there too
my Medutest report on the CPC vial came back 97.4 against a certificate saying 96.8
for the archive STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
what did SELECT actually measure, i see it quoted for everything
my 5 vial in 2.5ml gives 2.5mg/ml so 0.5 lands on 8 units, thats why i picked that volume
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is 2.4 the top or do people go past it
*Janoshik not the other one
i dont think the plateau is a dose problem most of the time, but i cant prove that
back after 23 months off, do i restart at 0.25 or somewhere higher
half life is about a week so youre roughly four to five weeks to steady state on any new dose
anyone compared their 2.5 vial dosing against the pen increments
steady state takes weeks
anyone gone from 2 straight to 0.25 or is that too big a jump
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg15 months at 2.4 and the honest summary is diminishing returns after the first half
restarted after 5 months off at a low dose and the nausea arrived exactly like the first time
£240 a month for compounded against what brand costs locally is why most people here use vials, anyway
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
mine faded too
On this day 4 years ago this channel logged 103 messages.