im at 15 and stuck, did anyone break a plateau without going up
#semaglutide 2026-06-10
Wednesday72 messages13 participantstimes are UTC
Highlights from this day
- mira_pins — the plateau hit me at 10 weeks and moved again about a month later without a dose change 19:47
- a1c_lag — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, i think 20:25
- septum_sal — i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it, we shall see 21:29
same dose day
thats STEP 1
back after 17 months off, do i restart at 0.25 or somewhere higher
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
seven days ish
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
how many weeks before you noticed anything at 1
😂18
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
ok so did the STEP 4 withdrawal arm show what i think it showed
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
im 7 months in at 1 and the appetite effect faded, is that a thing
held there too
STEP 1 ran to 68 weeks. thats the one everyone half remembers
slightly off topic but steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, i have it written down somewhere
how long till steady state, ive read the half life is about a week
did anyone titrate slower than four weeks a step and how did that go
not the same trial
the plateau hit me at 10 weeks and moved again about a month later without a dose change
🎉7💀12
26 months at 2.4 and the honest summary is diminishing returns after the first half
*PeptideMeter not the other one
anyone compared their 2 vial dosing against the pen increments
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genuine question held at 1 and lost 98lb over 3 months, slower than the trials and fine by me
whats the actual licensed ceiling, i keep seeing different numbers
did anyone hold at 7.5 longer than four weeks before going up
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mghow did people handle the jump from 1 to 1.7
does the licensed ceiling for weight differ from the diabetes one
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
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the long half life flattens the trough more than people expect, i never felt a day seven dip
does moving my dose day by two days matter with a seven day half life
my 20 vial in 1.5ml gives 8mg/ml so 0.5 lands on 15 units, thats why i picked that volume
weights-monthly.csv
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went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, i think
📈11🎉12
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
[edited]i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
*Janoshik not the other one
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, still working it out
does anyone actually run a five week step instead of four
vials not pens here
$94 a month for compounded against what brand costs locally is why most people here use vials
moving my dose day by a day or two never did anything noticeable for me
how long did the first 14kg take for people at the low doses
steady state takes weeks
give it four weeks
update on the earlier thing half life is about a week so youre roughly four to five weeks to steady state on any new dose
while im here is 2.4 the top or do people go past it
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i held at 7.5 for 7 months and it was the best decision i made, still working it out
SELECT wasnt weight
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
[edited]was SURMOUNT-OSA the one that ran to 68 weeks or am i mixing them up
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i dont think the plateau is a dose problem most of the time, but i cant prove that, ill dig out the number
i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it, we shall see
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2.4 is the ceiling
coa-f-1330.pdf
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my VendorInvestigate report on the JEEP vial came back 98.6 against a certificate saying 99.2
slower worked better
went too fast once
brand vs compounded, is there a difference people can actually feel
plateaus move
the appetite effect faded for me around 10 months and going up fixed it for a while
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
compounded and brand felt the same to me at 5, which is one person and nothing more
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
did anybody find a difference between SSA and pharmacy at the same 0.5
lost about 5kg on the low doses before i even got to 1, which surprised me, your mileage will differ
ok so is there a reason to hold at 1.7 rather than going to 2.4
restarted after 8 months off at a low dose and the nausea arrived exactly like the first time, your mileage will differ
what did SELECT actually measure, i see it quoted for everything
not the same trial
does the seven day half life mean the last two days are weaker
STEP is several trials, so saying STEP said x is usually wrong without a number after it
[edited]✅14📈1
went too fast once
[edited]🧊15🤝7
give it four weeks
thats STEP 1
the long half life flattens the trough more than people expect, i never felt a day seven dip