STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
#semaglutide 2026-05-24
Sunday50 messages9 participantstimes are UTC
Highlights from this day
- customs_owl — held at 5 and lost 79lb over 16 months, slower than the trials and fine by me 22:33
- customs_owl — went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, still working it out 23:11
- truncation_tru — went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, ask me again in a month 23:41
compounded and brand felt the same to me at 10, which is one person and nothing more
is there a reason to hold at 1.7 rather than going to 2.4
*PeptideMeter not the other one
not the same trial
STEP is several trials, so saying STEP said x is usually wrong without a number after it, from memory
five week steps worked better for me than four, purely on how the second week felt, happy to be corrected
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgSTEP 1 ran to 68 weeks. thats the one everyone half remembers
is 2.4 the top or do people go past it
slower worked better
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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ok so vial units and pen clicks are different systems, mixing the two is how people end up wrong
lost about 19kg on the low doses before i even got to 1, which surprised me, still working it out
held at 5 and lost 79lb over 16 months, slower than the trials and fine by me
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg🧪3
same dose day
is the plateau usually appetite coming back or just the scale stopping
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
my VendorInvestigate report on the WXT vial came back 98.1 against a certificate saying 99.4
i held at 2.4 for 9 months and it was the best decision i made
slightly off topic but if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, your mileage will differ
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, from memory
anyone compared their 10 vial dosing against the pen increments
how long till steady state, ive read the half life is about a week
mine faded too
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the appetite effect faded for me around 20 months and going up fixed it for a while
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
restarted after 2 months off at a low dose and the nausea arrived exactly like the first time, thats just me
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i stayed on 1.7 for 16 months and never went to 2.4, appetite was already where i needed it
my 2 vial in 1.5ml gives 2mg/ml so 2.4 lands on 15 units, thats why i picked that volume
give it four weeks
im 24 months in at 12 and the appetite effect faded, is that a thing
how many weeks before you noticed anything at 5
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step, still working it out
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2.4 is the ceiling
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thats STEP 1
*that should say weekly
seven days ish
did the STEP 4 withdrawal arm show what i think it showed
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went too fast once
moving my dose day by a day or two never did anything noticeable for me
vials not pens here
€185 a month for compounded against what brand costs locally is why most people here use vials
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
five week steps worked better for me than four, purely on how the second week felt
dose day is sunday for me only because thats when i remember, not because sunday matters, ill dig out the number
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down, ask me again in a month
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plateaus move
brand vs compounded, is there a difference people can actually feel
i stayed on 1.7 for 24 months and never went to 2.4, appetite was already where i needed it
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SELECT wasnt weight, someone check my working
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