licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
#semaglutide 2026-05-22
Friday34 messages8 participantstimes are UTC
Highlights from this day
- a1c_lag — genuine question moving my dose day by a day or two never did anything noticeable for me 11:59
- halifax_hplc — right so STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping 12:33
- otto_swirls — is there a reason to hold at 1.7 rather than going to 2.4 14:37
- bolus_bo — lost about 15kg on the low doses before i even got to 1, which surprised me 14:59
the plateau hit me at 23 weeks and moved again about a month later without a dose change, happy to be corrected
restarted after 13 months off at a low dose and the nausea arrived exactly like the first time
2.4 is the ceiling
genuine question moving my dose day by a day or two never did anything noticeable for me
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2 months at 2.4 and the honest summary is diminishing returns after the first half
did anybody find a difference between QSC and pharmacy at the same 2
went too fast once
half life is about a week so youre roughly four to five weeks to steady state on any new dose
im at 10 and stuck, did anyone break a plateau without going up
give it four weeks
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how long did the first 38kg take for people at the low doses
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
right so STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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vials not pens here
held at 2.4 and lost 27lb over 12 months, slower than the trials and fine by me
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
[edited]my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
held there too
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the long half life flattens the trough more than people expect, i never felt a day seven dip, from memory
not the same trial
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back after 16 months off, do i restart at 0.25 or somewhere higher
$38 a month for compounded against what brand costs locally is why most people here use vials, anyway
i dont think the plateau is a dose problem most of the time, but i cant prove that
the appetite effect faded for me around 11 months and going up fixed it for a while
plateaus move
how long till steady state, ive read the half life is about a week
thats STEP 1
i dont think the plateau is a dose problem most of the time, but i cant prove that
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compounded and brand felt the same to me at 0.25, which is one person and nothing more
is there a reason to hold at 1.7 rather than going to 2.4
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coming back to this vial units and pen clicks are different systems, mixing the two is how people end up wrong
seven days ish
sorry to jump in went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
lost about 15kg on the low doses before i even got to 1, which surprised me
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unrelated but i held at 0.25 for 4 months and it was the best decision i made