changed my mind on the four week rule, i think it depends entirely on how the current dose feels
#semaglutide 2026-05-17
Sunday38 messages8 participantstimes are UTC
Highlights from this day
- iris_imports — how did people handle the jump from 1 to 1.7 12:30
- iris_imports — restarted after 7 months off at a low dose and the nausea arrived exactly like the first time STEP is several trials, so saying STEP said x is usually wrong without a… 12:32
- deadspace — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 13:59
- VialBot — Digest for the week of 2026-04-10 has been published. 15:00
- chlorhex — is the plateau at 11 weeks normal or am i doing something wrong my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 16:46
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
how did people handle the jump from 1 to 1.7
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2.4 is the ceiling
restarted after 7 months off at a low dose and the nausea arrived exactly like the first time
STEP is several trials, so saying STEP said x is usually wrong without a number after it
did the STEP 4 withdrawal arm show what i think it showed
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, ymmv
was STEP 1 the one that ran to 68 weeks or am i mixing them up
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
did anyone titrate slower than four weeks a step and how did that go
brand vs compounded, is there a difference people can actually feel
vials not pens here
compounded and brand felt the same to me at 10, which is one person and nothing more
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
lost about 29kg on the low doses before i even got to 1, which surprised me
mine faded too
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
same dose day
genuine question does moving my dose day by two days matter with a seven day half life
back after 18 months off, do i restart at 0.25 or somewhere higher
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
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not the same trial
does the licensed ceiling for weight differ from the diabetes one
SELECT wasnt weight
is the plateau usually appetite coming back or just the scale stopping
16 months at 2.4 and the honest summary is diminishing returns after the first half
Digest for the week of 2026-04-10 has been published.
the appetite effect faded for me around 10 months and going up fixed it for a while, thats one data point
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
give it four weeks
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
does the seven day half life mean the last two days are weaker
while im here i stayed on 1.7 for 19 months and never went to 2.4, appetite was already where i needed it
is the plateau at 11 weeks normal or am i doing something wrong
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
16:48chlorhex pinned a message to this channel
the long half life flattens the trough more than people expect, i never felt a day seven dip
went too fast once
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moving my dose day by a day or two never did anything noticeable for me