£185 a month for compounded against what brand costs locally is why most people here use vials
#semaglutide 2026-05-05
Tuesday67 messages11 participantstimes are UTC
Highlights from this day
- tyne_tracks — i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication 20:24
- tyne_tracks — back after 20 months off, do i restart at 0.25 or somewhere higher 20:31
- split_dose_sam — coming back to this my Janoshik report on the SGN vial came back 98.6 against a certificate saying 99.4 21:16
- bolus_bo — vial units and pen clicks are different systems, mixing the two is how people end up wrong 21:27
not the same trial
restarted after 11 months off at a low dose and the nausea arrived exactly like the first time, we shall see
thats STEP 1
2.4 is the ceiling
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*Medutest not the other one
quick one moving my dose day by a day or two never did anything noticeable for me
STEP is several trials, so saying STEP said x is usually wrong without a number after it, ill dig out the number
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
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held there too
how long till steady state, ive read the half life is about a week
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is the plateau usually appetite coming back or just the scale stopping
the plateau hit me at 12 weeks and moved again about a month later without a dose change
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FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
SELECT wasnt weight
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, thats one data point
*Janoshik not the other one
mine faded too
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
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did the STEP 4 withdrawal arm show what i think it showed
back after 20 months off, do i restart at 0.25 or somewhere higher
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held at 0.25 and lost 14lb over 6 months, slower than the trials and fine by me
sorry to jump in the appetite effect faded for me around 7 months and going up fixed it for a while
whats the actual licensed ceiling, i keep seeing different numbers
half life is about a week so youre roughly four to five weeks to steady state on any new dose
i held at 7.5 for 4 months and it was the best decision i made
while im here was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up
slower worked better
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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coming back to this how many weeks before you noticed anything at 0.25
Testing queue: 4 submissions open, 39 awaiting dispatch.
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brand vs compounded, is there a difference people can actually feel
half life is about a week so youre roughly four to five weeks to steady state on any new dose
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coming back to this my Janoshik report on the SGN vial came back 98.6 against a certificate saying 99.4
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mglicensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
is 2.4 the top or do people go past it
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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22 months at 2.4 and the honest summary is diminishing returns after the first half
plateaus move
vials not pens here
lost about 7kg on the low doses before i even got to 1, which surprised me
give it four weeks
i stayed on 1.7 for 9 months and never went to 2.4, appetite was already where i needed it
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
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steady state takes weeks
my 30 vial in 1ml gives 5mg/ml so 0.5 lands on 40 units, thats why i picked that volume
lot-log.csv
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STEP 1 ran to 68 weeks. thats the one everyone half remembers
the long half life flattens the trough more than people expect, i never felt a day seven dip
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
i dont think the plateau is a dose problem most of the time, but i cant prove that
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how long did the first 44kg take for people at the low doses
i stayed on 1.7 for 17 months and never went to 2.4, appetite was already where i needed it
my dose day drifted from friday to sunday, does that reset anything
does anyone actually run a five week step instead of four
same dose day
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five week steps worked better for me than four, purely on how the second week felt
ok so dose day is sunday for me only because thats when i remember, not because sunday matters, n of 1 obviously
what did SELECT actually measure, i see it quoted for everything
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
did anyone hold at 2.4 longer than four weeks before going up
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgwent too fast once
compounded and brand felt the same to me at 2.4, which is one person and nothing more