held at 2.5 and lost 37lb over 6 months, slower than the trials and fine by me
#semaglutide 2026-04-30
Thursday54 messages9 participantstimes are UTC
Highlights from this day
- verify_or_dont — FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure 22:28
- dana_titrates — restarted after 6 months off at a low dose and the nausea arrived exactly like the first time 22:34
- dana_titrates — my VendorInvestigate report on the QYB vial came back 98.6 against a certificate saying 96.8, still working it out the appetite effect faded for me around 10 months… 22:35
- split_shipment — 3 months at 2.4 and the honest summary is diminishing returns after the first half 23:42
steady state takes weeks
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went too fast once
did anyone titrate slower than four weeks a step and how did that go
i stayed on 1.7 for 26 months and never went to 2.4, appetite was already where i needed it
how long till steady state, ive read the half life is about a week
brand vs compounded, is there a difference people can actually feel
not the same trial
compounded and brand felt the same to me at 2.4, which is one person and nothing more, from memory
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
plateaus move
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is the plateau at 2 weeks normal or am i doing something wrong
slightly off topic but does the seven day half life mean the last two days are weaker
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
restarted after 6 months off at a low dose and the nausea arrived exactly like the first time
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my VendorInvestigate report on the QYB vial came back 98.6 against a certificate saying 96.8, still working it out
the appetite effect faded for me around 10 months and going up fixed it for a while
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im 16 months in at 10 and the appetite effect faded, is that a thing
how many weeks before you noticed anything at 0.5
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing, thats one data point
slower worked better
Assay note: SWB lot H-2814 reported at 99% of label content.
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ok so moving my dose day by a day or two never did anything noticeable for me
how did people handle the jump from 1 to 1.7
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
my 40 vial in 2ml gives 4mg/ml so 12 lands on 30 units, thats why i picked that volume, i could be wrong
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same dose day
how long did the first 36kg take for people at the low doses
give it four weeks
the long half life flattens the trough more than people expect, i never felt a day seven dip
mine faded too
the appetite effect faded for me around 3 months and going up fixed it for a while
dose day is sunday for me only because thats when i remember, not because sunday matters
seven days ish
i held at 0.25 for 5 months and it was the best decision i made
€72 a month for compounded against what brand costs locally is why most people here use vials
five week steps worked better for me than four, purely on how the second week felt
vials not pens here
the plateau hit me at 6 weeks and moved again about a month later without a dose change
SELECT wasnt weight
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lost about 34kg on the low doses before i even got to 1, which surprised me
unrelated but does the licensed ceiling for weight differ from the diabetes one
coming back to this my dose day drifted from friday to sunday, does that reset anything
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
*week 13 not week 2
what did SELECT actually measure, i see it quoted for everything
im at 0.25 and stuck, did anyone break a plateau without going up
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
i held at 5 for 7 months and it was the best decision i made
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3 months at 2.4 and the honest summary is diminishing returns after the first half
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