does anyone actually run a five week step instead of four
#semaglutide 2026-04-15
Wednesday72 messages13 participantstimes are UTC
Highlights from this day
- a1c_lag — for the archive lost about 34kg on the low doses before i even got to 1, which surprised me 18:18
- vik_verifies — restarted after 22 months off at a low dose and the nausea arrived exactly like the first time 18:55
- sulphur_burp — steady state is the bit people skip, judging a new dose after eight days tells you almost nothing 18:58
- vik_verifies — STEP 1 ran to 68 weeks. thats the one everyone half remembers 20:11
- mira_pins — update on the earlier thing does the licensed ceiling for weight differ from the diabetes one 21:26
my 30 vial in 2.5ml gives 2.5mg/ml so 0.25 lands on 20 units, thats why i picked that volume
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
follow up STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
held there too
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
the appetite effect faded for me around 20 months and going up fixed it for a while, thats one data point
[edited]five week steps worked better for me than four, purely on how the second week felt, your mileage will differ
steady state takes weeks
✅17📉2
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
11 months at 2.4 and the honest summary is diminishing returns after the first half
how long till steady state, ive read the half life is about a week
is the plateau usually appetite coming back or just the scale stopping
how did people handle the jump from 1 to 1.7
for the archive lost about 34kg on the low doses before i even got to 1, which surprised me
🙏2🧪12🔥2
i stayed on 1.7 for 6 months and never went to 2.4, appetite was already where i needed it, i think
held at 1 and lost 81lb over 15 months, slower than the trials and fine by me
how long did the first 7kg take for people at the low doses
my dose day drifted from friday to sunday, does that reset anything
thats STEP 1
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
brand vs compounded, is there a difference people can actually feel
back after 19 months off, do i restart at 0.25 or somewhere higher
quick one going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
i dont think the plateau is a dose problem most of the time, but i cant prove that
restarted after 22 months off at a low dose and the nausea arrived exactly like the first time
🎉16📉6
im 24 months in at 5 and the appetite effect faded, is that a thing
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
❤️15✅6
quick one how many weeks before you noticed anything at 10
went too fast once
same dose day
not the same trial
was FLOW the one that ran to 68 weeks or am i mixing them up
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
2.4 is the ceiling
📉14🎉8😂5
dose day is sunday for me only because thats when i remember, not because sunday matters
my VendorInvestigate report on the JEEP vial came back 97.4 against a certificate saying 98.6
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
anyone compared their 2 vial dosing against the pen increments
does the seven day half life mean the last two days are weaker
plateaus move
moving my dose day by a day or two never did anything noticeable for me
✅10
while im here the plateau hit me at 4 weeks and moved again about a month later without a dose change
[edited]while im here half life is about a week so youre roughly four to five weeks to steady state on any new dose
for the archive compounded and brand felt the same to me at 15, which is one person and nothing more, ill dig out the number
is 2.4 the top or do people go past it
slightly off topic but £240 a month for compounded against what brand costs locally is why most people here use vials
🧪4
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing, i could be wrong
the long half life flattens the trough more than people expect, i never felt a day seven dip
STEP 1 ran to 68 weeks. thats the one everyone half remembers
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
👍5❤️8🙏2
mine faded too
anyone gone from 7.5 straight to 2.5 or is that too big a jump
give it four weeks
SELECT wasnt weight
[edited]if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
changed my mind on the four week rule, i think it depends entirely on how the current dose feels, ask me again in a month
chromatogram-overlay.png
1240 × 720 · 726 KB · not retained in the public archive
held there too
STEP 1 ran to 68 weeks. thats the one everyone half remembers
STEP is several trials, so saying STEP said x is usually wrong without a number after it
slower worked better
seven days ish, i have it written down somewhere
slower worked better
vials not pens here
dose day is sunday for me only because thats when i remember, not because sunday matters
i held at 0.25 for 4 months and it was the best decision i made
i dont think the plateau is a dose problem most of the time, but i cant prove that
update on the earlier thing does the licensed ceiling for weight differ from the diabetes one
❤️18
ok so give it four weeks
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
genuine question plateaus move
coming back to this vials not pens here
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
SELECT wasnt weight
slower worked better
👍1