vialroom

#semaglutide 2026-03-27

Friday21 messages4 participantstimes are UTC
Highlights from this day
  • leeds_ledger — i stayed on 1.7 for 18 months and never went to 2.4, appetite was already where i needed it 20:27
  • leeds_ledger — how many weeks before you noticed anything at 2 20:51
  • leeds_ledger — went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step 21:18
LL

im 17 months in at 2.4 and the appetite effect faded, is that a thing

sorry to jump in restarted after 19 months off at a low dose and the nausea arrived exactly like the first time

update on the earlier thing FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure

MM

what did SELECT actually measure, i see it quoted for everything

MM

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule, thats just me

LL

did anybody find a difference between Homopeptide and pharmacy at the same 7.5

LL

i stayed on 1.7 for 18 months and never went to 2.4, appetite was already where i needed it

Cited study
Tirzepatide versus Semaglutide Once Weekly in Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
The head-to-head everyone quotes. Note the semaglutide comparator dose.
MM

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

went too fast once

not the same trial

how many weeks before you noticed anything at 2

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MM

lost about 8kg on the low doses before i even got to 1, which surprised me

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LL

went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step

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MM

did the STEP 4 withdrawal arm show what i think it showed

quick one half life is about a week so youre roughly four to five weeks to steady state on any new dose

MM

i dont think the plateau is a dose problem most of the time, but i cant prove that

VB

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