went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
#semaglutide 2026-03-17
Tuesday67 messages12 participantstimes are UTC
Highlights from this day
- food_noise_off — unrelated but the plateau hit me at 16 weeks and moved again about a month later without a dose change 10:16
- pbs_pip — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 10:29
- pbs_pip — right so my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 15:22
- marrow.mod — moving my dose day by a day or two never did anything noticeable for me 17:20
- marrow.mod — the long half life flattens the trough more than people expect, i never felt a day seven dip five week steps worked better for me than four, purely on how the second… 17:49
i dont think the plateau is a dose problem most of the time, but i cant prove that
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thats STEP 1
seven days ish
does moving my dose day by two days matter with a seven day half life
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure, thats one data point
compounded and brand felt the same to me at 1.7, which is one person and nothing more
how did people handle the jump from 1 to 1.7
unrelated but the plateau hit me at 16 weeks and moved again about a month later without a dose change
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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genuine question my Janoshik report on the WWB vial came back 99 against a certificate saying 96.8
went too fast once
whats the actual licensed ceiling, i keep seeing different numbers
half life is about a week so youre roughly four to five weeks to steady state on any new dose
my dose day drifted from friday to sunday, does that reset anything
sorry to jump in is 2.4 the top or do people go past it
how long did the first 28kg take for people at the low doses
*PeptideMeter not the other one
genuine question was SELECT the one that ran to 68 weeks or am i mixing them up
11:42marrow.mod pinned a message
held there too
i held at 12 for 4 months and it was the best decision i made
*VendorInvestigate not the other one
how long till steady state, ive read the half life is about a week
if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
sorry to jump in SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
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did the STEP 4 withdrawal arm show what i think it showed
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
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licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
13 months at 2.4 and the honest summary is diminishing returns after the first half
lost about 3kg on the low doses before i even got to 1, which surprised me
did anybody find a difference between SGN and pharmacy at the same 5
not the same trial
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
slower worked better
mine faded too
STEP 1 ran to 68 weeks. thats the one everyone half remembers, anyway
plateaus move
unrelated but my 10 vial in 1.5ml gives 8mg/ml so 2 lands on 5 units, thats why i picked that volume
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, thats one data point
im at 7.5 and stuck, did anyone break a plateau without going up
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five week steps worked better for me than four, purely on how the second week felt
right so my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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is the plateau at 34 weeks normal or am i doing something wrong
steady state takes weeks
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vials not pens here
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
anyone compared their 4 vial dosing against the pen increments
does the licensed ceiling for weight differ from the diabetes one
held at 15 and lost 18lb over 25 months, slower than the trials and fine by me
[edited]what did SELECT actually measure, i see it quoted for everything
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is the plateau usually appetite coming back or just the scale stopping
moving my dose day by a day or two never did anything noticeable for me
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STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
the long half life flattens the trough more than people expect, i never felt a day seven dip
five week steps worked better for me than four, purely on how the second week felt
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2.4 is the ceiling
same dose day
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did anyone hold at 15 longer than four weeks before going up
quick one €94 a month for compounded against what brand costs locally is why most people here use vials
brand vs compounded, is there a difference people can actually feel
lot-log.csv
454 rows · not retained in the public archive
right so how many weeks before you noticed anything at 15
for the archive compounded and brand felt the same to me at 1, which is one person and nothing more
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is there a reason to hold at 1.7 rather than going to 2.4
slower worked better
[edited]SELECT wasnt weight
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vial units and pen clicks are different systems, mixing the two is how people end up wrong
thats STEP 1
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dose day is sunday for me only because thats when i remember, not because sunday matters