unrelated but STEP is several trials, so saying STEP said x is usually wrong without a number after it
#semaglutide 2026-03-13
Friday56 messages12 participantstimes are UTC
Highlights from this day
- panel_before_after — my PeptideMeter report on the Homopeptide vial came back 96.8 against a certificate saying 97.4 17:21
- panel_before_after — five week steps worked better for me than four, purely on how the second week felt 17:24
- meniscus_mel — slightly off topic but did anyone hold at 0.25 longer than four weeks before going up 18:19
- fake_tracking — is 2.4 the top or do people go past it 19:10
- cold_start_cy — ok so if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule 23:58
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
my PeptideMeter report on the Homopeptide vial came back 96.8 against a certificate saying 97.4
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
five week steps worked better for me than four, purely on how the second week felt
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brand vs compounded, is there a difference people can actually feel
Archive lookup: surpass_two first appears in this channel on 2025-10-23.
ok so is the plateau at 2 weeks normal or am i doing something wrong
the appetite effect faded for me around 10 months and going up fixed it for a while
10 months at 2.4 and the honest summary is diminishing returns after the first half
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
vials not pens here
genuine question anyone compared their 4 vial dosing against the pen increments
slightly off topic but did anyone hold at 0.25 longer than four weeks before going up
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held at 2.4 and lost 29lb over 10 months, slower than the trials and fine by me
steady state takes weeks
going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution, ill dig out the number
unrelated but the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
sorry to jump in the plateau hit me at 18 weeks and moved again about a month later without a dose change, ask me again in a month
does anyone actually run a five week step instead of four
went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
im at 1 and stuck, did anyone break a plateau without going up
is 2.4 the top or do people go past it
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panel_before_afterfive week steps worked better for me than four, purely on how the second week felt
i dont think the plateau is a dose problem most of the time, but i cant prove that, ymmv
i held at 2 for 9 months and it was the best decision i made
seven days ish
sorry to jump in STEP 1 ran to 68 weeks. thats the one everyone half remembers
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial, i think
my 20 vial in 2ml gives 10mg/ml so 15 lands on 8 units, thats why i picked that volume
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whats the actual licensed ceiling, i keep seeing different numbers
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€120 a month for compounded against what brand costs locally is why most people here use vials
does moving my dose day by two days matter with a seven day half life
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compounded and brand felt the same to me at 5, which is one person and nothing more
im 10 months in at 12 and the appetite effect faded, is that a thing
lost about 20kg on the low doses before i even got to 1, which surprised me
did anybody find a difference between JEEP and pharmacy at the same 15
two_four_ceilingmy 20 vial in 2ml gives 10mg/ml so 15 lands on 8 units, thats why i picked that volume
half life is about a week so youre roughly four to five weeks to steady state on any new dose
went too fast once
thats STEP 1
held there too
back after 22 months off, do i restart at 0.25 or somewhere higher
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
plateaus move
was STEP 1 the one that ran to 68 weeks or am i mixing them up
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
does the licensed ceiling for weight differ from the diabetes one
restarted after 24 months off at a low dose and the nausea arrived exactly like the first time
slightly off topic but the long half life flattens the trough more than people expect, i never felt a day seven dip
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mine faded too
genuine question steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
not the same trial, happy to be corrected
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anyone gone from 1.7 straight to 1 or is that too big a jump
is there a reason to hold at 1.7 rather than going to 2.4
ok so if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg