vialroom

#semaglutide 2026-03-11

Wednesday34 messages6 participantstimes are UTC
Highlights from this day
  • sgp_subq — changed my mind on the four week rule, i think it depends entirely on how the current dose feels, i think 09:41
  • first_vial_finn — does the seven day half life mean the last two days are weaker 09:50
  • vial_ledger — dose day is sunday for me only because thats when i remember, not because sunday matters 10:28
  • first_vial_finn — back after 5 months off, do i restart at 0.25 or somewhere higher 10:34
  • taper_tess — im 26 months in at 1 and the appetite effect faded, is that a thing 10:57
TT

anyone compared their 10 vial dosing against the pen increments

SS

licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose

SS

im at 0.5 and stuck, did anyone break a plateau without going up

does the licensed ceiling for weight differ from the diabetes one

STEP is several trials, so saying STEP said x is usually wrong without a number after it

SS

changed my mind on the four week rule, i think it depends entirely on how the current dose feels, i think

fridge-temps.csv
500 rows · not retained in the public archive
FV

does the seven day half life mean the last two days are weaker

Cited study
Semaglutide vs Liraglutide for Weight Loss in Adults with Overweight or Obesity (STEP 8)
JAMA · 2022
Weekly against daily, head to head.

*week 26 not week 8

VL

dose day is sunday for me only because thats when i remember, not because sunday matters

❤️7🎉5
HL

going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution

HL

compounded and brand felt the same to me at 15, which is one person and nothing more

TT

i dont think the plateau is a dose problem most of the time, but i cant prove that

TT

im 26 months in at 1 and the appetite effect faded, is that a thing

🔥3🧊2📈7

is the plateau at 4 weeks normal or am i doing something wrong

HL

is the plateau usually appetite coming back or just the scale stopping

SS

my 40 vial in 3ml gives 2mg/ml so 5 lands on 20 units, thats why i picked that volume

my dose day drifted from friday to sunday, does that reset anything

🔥1📈8
FV

half life is about a week so youre roughly four to five weeks to steady state on any new dose, we shall see

SS

genuine question STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping

SS

did the STEP 4 withdrawal arm show what i think it showed

does moving my dose day by two days matter with a seven day half life
restarted after 23 months off at a low dose and the nausea arrived exactly like the first time

anyone gone from 0.5 straight to 10 or is that too big a jump

the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing

if youre comparing brand to compounded, dose accuracy in the vial is the variable, not the molecule