plateaus move
#semaglutide 2026-02-18
Wednesday22 messages6 participantstimes are UTC
Highlights from this day
- factory_direct_fi — vial units and pen clicks are different systems, mixing the two is how people end up wrong 13:41
- VialBot — Recon calculator: 15mg in 0.5ml = 4mg/ml. 14:23
- split_dose_sam — whats the actual licensed ceiling, i keep seeing different numbers 15:36
- split_dose_sam — dose day is sunday for me only because thats when i remember, not because sunday matters 15:38
the appetite effect faded for me around 14 months and going up fixed it for a while, someone check my working
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
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vials not pens here
restarted after 24 months off at a low dose and the nausea arrived exactly like the first time
is 2.4 the top or do people go past it
£55 a month for compounded against what brand costs locally is why most people here use vials
licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
while im here did anybody find a difference between QST and pharmacy at the same 2
right so STEP is several trials, so saying STEP said x is usually wrong without a number after it
vial units and pen clicks are different systems, mixing the two is how people end up wrong
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held there too
the long half life flattens the trough more than people expect, i never felt a day seven dip
STEP 1 ran to 68 weeks. thats the one everyone half remembers
Recon calculator: 15mg in 0.5ml = 4mg/ml.
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half life is about a week so youre roughly four to five weeks to steady state on any new dose
whats the actual licensed ceiling, i keep seeing different numbers
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dose day is sunday for me only because thats when i remember, not because sunday matters
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
7 months at 2.4 and the honest summary is diminishing returns after the first half
slower worked better
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
anyone gone from 1.7 straight to 12 or is that too big a jump
ok so i stayed on 1.7 for 4 months and never went to 2.4, appetite was already where i needed it